This study is looking at new ways to understand Chronic Lung Allograft Dysfunction (CLAD), a lung problem that can happen after a lung transplant. Researchers want to see if special MRI scans, including Oxygen enhanced magnetic resonance imaging (OE-MRI) and 129Xe MRI scans, along with a Contrast Lung Computed Tomography (CT) Scan, can help diagnose CLAD. The main goal is to see if these imaging methods can show changes in your lung function, specifically your Forced expiratory volume in 1 second (FEV1), over three months. You might be able to join if you are 18-80 years old, speak English, are a non-smoker, and have had a bilateral lung transplant at least 6 months ago. The study is currently recruiting 100 participants.

Study design

This interventional study plans to enroll 100 participants to evaluate different imaging techniques.

What's involved

You will have vital signs taken, complete questionnaires, undergo spirometry (a breathing test), a Contrast Lung CT Scan, and one MRI session with six different scans, including OE-MRI and 129Xe MRI.

Compensation

Not stated in the trial record.

Follow-up

Your FEV1 will be measured at the beginning of the study and again after 3 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.