This study, called APPLE, is looking at whether taking a specific dose of aspirin early in pregnancy can help prevent pre-eclampsia (a serious blood pressure condition during pregnancy) and pregnancy loss. Researchers want to see if starting 162 mg of aspirin very early in pregnancy (before 6 weeks and 6 days) or a placebo followed by 81 mg of aspirin later, is more effective than standard recommendations. You might be able to join if you are a woman between 18 and 45 years old, are less than 6 weeks and 6 days pregnant, and are willing to take oral medication. The study will measure if pre-eclampsia occurs between 20 weeks of pregnancy and delivery, and if pregnancy loss occurs from enrollment up to 24 weeks of gestation. The study aims to enroll 1150 participants, but its current status is unclear.

Study design

This interventional study plans to enroll 1150 women. Participants will receive either 162 mg of aspirin or a placebo followed by 81 mg of aspirin.

What's involved

You would need to take oral medication (aspirin or placebo) daily from early pregnancy until delivery. You would also need to comply with all study procedures.

Compensation

Not stated in the trial record.

Follow-up

The study will track pre-eclampsia from 20 weeks of pregnancy until delivery, and pregnancy loss from enrollment up to 24 weeks of gestation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.