Observational Study of Indocyanine Green Dye for Sarcoma Resection

This study is looking at how well a special dye, indocyanine green (ICG), helps surgeons remove bone or soft tissue sarcomas. ICG is used during surgery to see if all the tumor has been removed. Researchers want to see if the dye's results during surgery match what doctors find later when they examine the removed tissue. You might be able to join if you are 18 or older, have a confirmed bone or soft tissue sarcoma, and are having surgery to remove it. You cannot join if you have chronic kidney disease or are allergic to dyes. The study aims to enroll 50 participants, but its current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without giving new treatments. It plans to include 50 participants.
What's involved
You would receive an ICG infusion before your scheduled surgery, and your medical records will be reviewed.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, which is the accuracy of ICG fluorescence, is measured at Baseline (during surgery).

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NCT06409013

Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~75 participants
Updated 2026-08-04 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Accuracy of intraoperative ICG fluorescence compared to final pathology results
Measured over Baseline
Bone Sarcoma
Soft Tissue Sarcoma
1 sites across 1 states
Minnesota1
  • Matthew T. Houdek, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic in Rochester

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Eligibility criteria

Inclusion

Patients with biopsy-proven bone or soft tissue sarcoma undergoing resection

Exclusion

Chronic kidney disease
Anaphylaxis to dyes
  • Accuracy of intraoperative ICG fluorescence compared to final pathology resultsBaseline

    Intraoperative ICG fluorescence and deduced margins will be analyzed and compared the accuracy to final pathology margins. Negative predictive value will be calculated.