FAPI-74 PET/CT Imaging for Fibrosis
This study is looking at how a special imaging scan, called FAPI-74 PET/CT, can help doctors see fibrosis (scarring of tissues) in adults. Fibrosis can be caused by many medical conditions and can lead to health problems. The FAPI-74 PET/CT scan uses a substance called [F-18]-FAPI-74 to highlight areas of fibrosis in the body. Researchers want to see if this scan can accurately show where fibrosis is located in people with conditions like certain head and neck cancers or PTLD (Post-Transplant Lymphoproliferative Disorder). The study will follow participants for 3 years to analyze the scan results. This is an observational study, meaning the scan results won't directly change your treatment, but will help doctors learn more about fibrosis.
- Study design
- This is an interventional study with a planned enrollment of 45 participants. It is designed as a 'basket protocol' to evaluate FAPI-74 PET/CT in different groups of patients with fibrosis.
- What's involved
- Participants will undergo a [F-18]-FAPI-74 PET/CT scan. The study will analyze the scan results over 3 years.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 3 years to analyze the FAPI-74 PET/CT image results.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
FAPI-74 PET/CT in Adults With Fibrosis
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Mark A Sellmyer, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
Who to contact
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What this trial measures
- Overall FAPI-74 PET/CT Image Analysis3 years
The overall quality of the generated images will be evaluated. Initial imaging of the vertex to mid-thigh will be used to investigate regional tracer uptake in suspected sites of fibrosis and normal tissues for this novel radiotracer. Uptake and retention of \[F-18\]-FAPI-74 in known or suspected sites of fibrotic disease will be evaluated visually by trained radiology readers, the principal investigator, or designee. A number of analysis methods may be tested to identify the optimal method for analyses for future studies with this radiotracer. \[F-18\]-FAPI-74 PET/CT scans will be interpreted both qualitatively and quantitatively.
- Head and Neck Cancer FAPI-74 PET/CT Image Analysis3 years
\[18F\]-FAPi74 PET/CT data: Areas of uptake in tumors and healthy tissue will be measured by SUVmax and semiquantitative analysis will be conducted. In each case, lesion uptake will be marked as low, medium, and high avidity. Each lesion and lymph node will be separately measured and quantified. Measurements will be made by Dr. Sellmyer and co-Investigators (n=3).
- PTLD FAPI-74 PET/CT Image Analysis3 years
Quantitative interpretation of FAP expression, will be recorded as a Standardized Uptake Value (SUV). Max, mean, and peak SUV values will be recorded for a region-of-interest encompassing a single primary lesion.