Solriamfetol for Binge Eating Disorder

This study is testing if solriamfetol can help adults with binge eating disorder (BED). Researchers want to see if taking solriamfetol (either 150 mg or 300 mg) once a day for 12 weeks can reduce the number of binge eating episodes compared to a placebo (an inactive pill). You could be eligible if you are 18 to 55 years old and have a primary diagnosis of BED. The study aims to enroll 450 participants. The current recruitment status is unclear.

Study design
This is a Phase 3, randomized, double-blind study, meaning participants are randomly assigned to receive solriamfetol or placebo, and neither you nor your doctor will know which you are receiving. It plans to include 450 participants.
What's involved
You would take solriamfetol tablets or a placebo once daily for 12 weeks. You must also provide written informed consent.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome is measured at 12 weeks, which is the duration of the treatment period.

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NCT06413433

Elucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol

Recruiting
PHASE3Ages 18–55InterventionalTreatment
Axsome Therapeutics, Inc.
~450 participants
Updated 2026-07-28 on ClinicalTrials.gov
What's tested:Solriamfetol 150 mgSolriamfetol 300 mgPlacebo

At a glance

Recruiting sites
38 of 45 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from Baseline to Week 12 in number of binge eating episodes
Measured over 12 weeks
Binge-Eating Disorder
45 sites across 18 states
Florida10
California8
Ohio4
Texas4
Massachusetts2
New Jersey2
New York2
Pennsylvania2

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Primary diagnosis of BED according to DSM-5 criteria.
Provides written informed consent to participate in the study before the conduct of any study procedures.
Male or female, aged 18 to 55 inclusive.

Exclusion

Prior exposure to solriamfetol/Sunosi, through either a clinical study or prescription.
Unable to comply with study procedures.
Medically inappropriate for study participation in the opinion of the investigator.
  • Change from Baseline to Week 12 in number of binge eating episodes12 weeks