CBD for Knee Osteoarthritis

This study is looking at whether Cannabidiol (CBD) Extract can help people with knee osteoarthritis (a common joint disease causing pain and disability). Researchers want to see if CBD Extract is safe, acceptable, and helps reduce knee pain. You might be able to join if you are between 40 and 75 years old, have a diagnosis of knee osteoarthritis, and experience moderate to severe knee pain. The study will compare CBD Extract to a placebo (an inactive substance that looks like the real treatment). Researchers will measure your pain levels and how you feel about the treatment over one month to see if CBD Extract is helpful. The current status of this study is unclear.

Study design
This interventional study plans to enroll 30 participants. It compares Cannabidiol (CBD) Extract to a placebo.
What's involved
You would take either Cannabidiol (CBD) Extract or a placebo three times daily with food, administered under the tongue. You would report on adverse events weekly for one month, and complete questionnaires and self-report pain ratings at the beginning and end of the month, and daily for one month.
Compensation
Not stated in the trial record.
Follow-up
Your pain and acceptability of treatment will be measured at baseline and one month, and adverse events will be monitored weekly for one month.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06414473

CBD for Knee Osteoarthritis

Recruiting
PHASE1Ages 40–75InterventionalTreatment
University of Florida
~30 participants
Updated 2025-09-17 on ClinicalTrials.gov
What's tested:Cannabidiol (CBD) ExtractPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)
Measured over Weekly until 1 month
+4 more outcomes measured
Osteoarthritis, Knee
1 sites across 1 states
Florida1

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  • Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)Weekly until 1 month

    Categorical scale, None or not at all (0) and very severe or very much (4), higher scores mean worse outcome

  • Theoretical Framework of Acceptability Questionnaire (TFAQ)Baseline and 1 month

    Likert scale, 1 and 5, higher scores mean worse outcome

  • Self-report Ratings of Knee PainBaseline and 1 month, daily until 1 month

    Numeric Rating Scale, 0 and 10, higher scores mean worse outcome

  • Physical ActivityDaily until 1 month

    Accelerometer measures step counts per day

  • Western Ontario and McMaster Universities Arthritis Index (WOMAC)Baseline and 1 month

    Categorical scale, none (0) and extreme (4), higher scores mean worse outcome