Study on Aging, Menopause, and Blood Vessel Responses to Low Oxygen

This study aims to understand how aging and menopause affect how your blood vessels respond to low oxygen levels (hypoxia). Researchers are looking at women who are pre-menopausal, peri-menopausal (around menopause), or post-menopausal. You might receive a placebo (an inactive pill), Propranolol (1 mg/kg), or Gemtesa (75 mg). The main goal is to measure changes in blood flow in your forearm after 5 minutes. To join, you must be a woman between 18 and 70 years old, with a healthy weight (BMI between 18 and 30). This study is currently recruiting participants.

Study design
This is an interventional study planning to enroll 75 women. Participants will receive either a placebo, Propranolol, or Gemtesa.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, forearm blood flow, is measured at 5 minutes after baseline.

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NCT06417177

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

Recruiting
EARLY_PHASE1Ages 18–70InterventionalBasic science
University of Missouri-Columbia
~75 participants
Updated 2025-09-09 on ClinicalTrials.gov
What's tested:PlaceboPropranololGemtesa

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Forearm blood flow
Measured over Change from baseline to 5 minutes.
Aging
Menopause
Hypoxia
Vasodilation
1 sites across 1 states
Missouri1

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Eligibility criteria

Inclusion

Female assigned at birth
Pre, peri- or post-menopausal
Healthy weight (BMI ≥18 and ≤30 kg/m2)

Exclusion

Male (assigned at birth)
Pregnancy, breastfeeding
Use of hormone replacement therapies
Hysterectomy
Body mass index \>30 kg/m2
Diagnosed sleep apnea
Current smoking/Nicotine/Drug use
Nerve/neurologic disease
Cardiovascular, hepatic, renal, respiratory disease
Blood pressure ≥140/90 mmHg
Diabetes, Polycystic ovarian syndrome
Communication barriers
Prescription medications
Malignant cancer
  • Forearm blood flowChange from baseline to 5 minutes.

    Blood flow in the forearm measured with venous occlusion plethysmography.