Standardized Clinical Assessment for Leptomeningeal Metastasis

This study aims to create a reliable way to assess the neurological health of patients with leptomeningeal metastasis (cancer that has spread to the fluid and membranes surrounding the brain and spinal cord). Researchers will use a 'Neurological Assessment' where two different evaluators will check your neurological status. The main goal is to see how well these evaluators agree on their findings, which will help create a consistent scoring system for future use in both research and patient care. You may be able to join if you are an adult with a confirmed diagnosis of cancer outside the brain and spinal cord, and have leptomeningeal metastasis. The study is currently unclear on its recruitment status.

Study design
This is an observational study planning to enroll 200 participants. It does not involve a new drug or treatment.
What's involved
You will undergo a clinical neurological assessment performed by two different raters.
Compensation
Not stated in the trial record.
Follow-up
The primary goal of the study is measured at December 2026, focusing on agreement between raters.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06417710

Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis

Recruiting
Not specifiedAges 18+Observational
University of Zurich
~200 participants
Updated 2024-05-16 on ClinicalTrials.gov
What's tested:Neurological Assessment

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
inter-observer agreement of response assessment of the overall clinical assessment - per center and among all raters
Measured over December 2026
Leptomeningeal Metastasis
Leptomeningeal Disease
Leptomeningeal Neoplasms
Leptomeningeal Cancer

NCT06417710

Where you'd take part

This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • MD Anderson Cancer Center

    Houston, Texasstudy coordinator listed

    Recruiting

  • Netherlands Cancer Institute

    Amsterdam, Netherlandsstudy coordinator listed

    Recruiting

  • University Hospital Zurich

    Zurich, Switzerlandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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Eligibility criteria

Inclusion

Adult patients (18 years or more), female or male
Histologically confirmed diagnosis of extra-CNS primary solid cancer
Diagnosis of leptomeningeal metastases confirmed or probable per EANO ESMO criteria
Performance status compatible with enrolment into clinical trials
Ability to consent
Signed informed consent form from patient
Participation in a parallel clinical trial is allowed in this non-interventional study

Exclusion

Inability to give informed consent
Inability to adhere to recommended follow-up according to the treating physician
  • inter-observer agreement of response assessment of the overall clinical assessment - per center and among all ratersDecember 2026