Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
This study, called HODNIRS, is looking at how Hodgkin Lymphoma (HL) survivors who received bleomycin and/or chest radiation therapy at St. Jude Children's Research Hospital are doing. Researchers want to understand if there's a connection between these past treatments and brain function. They will use a portable, non-invasive (meaning it doesn't go inside your body) device called Near-Infrared Spectroscopy (NIRS) to measure blood flow and oxygen in the brain during exercise. The study aims to compare these measurements in HL survivors to people who haven't had cancer. You might be able to join if you are an HL survivor treated at St. Jude, were under 21 at diagnosis, are now at least 18 and at least 2 years past treatment, and speak English. Community controls who are at least 18 years old can also join.
- Study design
- This is an observational study planning to include 100 participants, including Hodgkin Lymphoma survivors and community controls.
- What's involved
- You would have your brain blood flow and oxygen measured using a wearable NIRS device during physical activity at baseline.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors
At a glance
Conditions
NCT06421987
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
St. Jude Children's Research Hospital
Memphis, Tennesseestudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Nicholas Phillips, PhD · PRINCIPAL_INVESTIGATOR · St. Jude
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Near-Infrared Spectroscopy (NIRS)Baseline
a non-invasive imaging technology that is used to measure regional or global cerebral tissue oxygenation and cerebral blood flow (CBF) during exercise. NIRS takes advantage of the fact that oxygenated blood and de-oxygenated blood absorb light differently. By measuring the reflected light from blood, the concentration of both oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (HbdO2) using the modified Beer-Lambert Law can be calculated.