Study on Antioxidant Supplements and Blood Vessel Health in Healthy Adults
This study is looking at how antioxidant supplements affect blood vessel health in healthy adults, especially those who are non-Hispanic Black. Researchers are testing a supplement called MitoQ, a placebo (an inactive substance that looks like the real thing), and two drugs called MitoTempo and Tempol. They will also use L-NAME, which helps measure how blood vessels widen. The goal is to see if mitochondria (parts of your cells that produce energy) are involved in problems with blood vessel function. To join, you should be between 18 and 75 years old, identify as non-Hispanic Black or non-Hispanic White, and have healthy blood pressure and cholesterol levels. The study will measure how your blood vessels respond to heat, how well they widen, and mitochondrial activity in your blood cells.
- Study design
- This is an interventional study planning to enroll 60 healthy participants. It tests different dietary supplements and drugs to understand their effects.
- What's involved
- During each experimental visit, you will have MitoTempo, Tempol, or L-NAME infused into your forearm using a microdialysis technique. Blood vessel responses and blood cell activity will be measured.
- Compensation
- Not stated in the trial record.
- Follow-up
- Primary endpoints are measured at 1 hour post intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effects of an Antioxidant Supplement on Blood Vessel Health
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Cutaneous microvascular responses to local heating1 hour post intervention
Using intradermal microdialysis, skin blood vessels will be locally treated with a mitochondria-targeted antioxidant (MitoTempo; 1 mM concentration). Nitric oxide (NO)-mediated skin vasodilation will be quantified via local inhibition of endothelial NO synthase during the course of the local skin heating protocol using L-NAME (15 mM concentration). Finally, maximal skin blood flow will be measured by heating the local area of skin to 43 degrees Celsius and locally perfusing sodium nitroprusside (SNP; an NO donor; 28 mM concentration). Two (2) thin fiber optic laser Doppler flowmeter probes and their holders, containing local heaters, will be used to measure skin blood flow.
- Flow-mediated dilation responses1 hour post intervention
FMD measures the health of blood vessels. The ultrasound makes sound waves to measure the size of blood vessels and the speed of the blood during rest and occlusion. The cuff is inflated to 220 mmHg (a commonly-used suprasystolic pressure; i.e., arterial blood flow is completely occluded) for 5 minutes to stop blood flow to and from the forearm.
- Mitochondrial ROS production in peripheral blood mononuclear cells (PBMCs)1 hour post intervention
Blood will be drawn for isolation of PBMCs and measurement of mitochondrial function and oxidative stress production.