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Transcranial Focused Ultrasound (tFUS) for Individual Dosing

This study is testing a new way to use a device called Brainsonix Bx Pulsar machine tFUS. This device uses sound waves to stimulate the brain. Researchers want to find a simple way to know if the device is in the right spot and using the correct amount of stimulation for each person. They will see if the tFUS can temporarily create a small blind spot in your vision, called a scotoma. This scotoma would be used to figure out the lowest effective dose for you. The study is looking for 30 healthy volunteers between 18 and 70 years old with normal vision and hearing, and no history of neurological or mental health conditions. The study is currently unclear on its recruitment status.

Study design
This is an interventional study with 30 planned participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, temporary scotoma, is measured during and immediately after (10 minutes) the tFUS procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06426498

tFUS Induced Transient Scotoma for Individual Dosing

Recruiting
NAAges 18–70InterventionalBasic science
Medical University of South Carolina
~30 participants
Updated 2026-05-29 on ClinicalTrials.gov
What's tested:Brainsonix Bx Pulsar machine tFUS

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Temporary Scotoma
Measured over During and immediately after (10 minutes) the tFUS

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
South Carolina1

Who to contact

Bridgette Holland
[email protected]
843 638 7517
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Male or female
Age 18-70
Normal or corrected-to normal vision and hearing
No neurological or psychological illness

Exclusion

Diagnosis of any depressive or anxiety disorder
Diagnosis of schizophrenia or bipolar disorder
Current use of any non-prescribed psychoactive medications or drugs
Contraindication to enter the MRI environment.
Pregnancy (or suspected/possible pregnancy or plan to become pregnant in the short term).
Urine Pregnancy Test: If the subject is a woman of childbearing potential and /or a man capable of fathering a child before, during, and/or after participation precaution should be taken. Examples of acceptable methods of birth control for participants involved in the study include: birth control pills, patch, IUD, condom, sponge, diaphragm with spermicide, or avoiding sexual activity that could cause the subject to become pregnant.
Inability to adhere to treatment schedule.
Initiation of new antidepressant treatment at the time of study randomization.

What this trial measures

  • Temporary ScotomaDuring and immediately after (10 minutes) the tFUS

    Production of a temporary Scotoma as assessed by visual field testing of briefly presented objects in different quadrants while staring at a central cross on a computer screen.