Craving Network Neurofeedback for Overweight or Obesity

This study is testing if people with overweight or obesity and high food cravings can learn to change their brain's response to food using a technique called neurofeedback. Neurofeedback uses a device to show you your brain activity, like a thermometer, and teaches you to change it. Researchers want to see if this can reduce food cravings and change eating habits. You might be able to join if you are 18 to 60 years old, have a body mass index (BMI) over 25, and a high score on a food craving questionnaire. The study aims to see if neurofeedback can reduce the strength of your brain's craving network, lower your food cravings, and improve your eating behavior. This study is currently unclear on its recruitment status and plans to enroll 50 participants.

Study design
This interventional study plans to enroll 50 participants. Some participants will receive experimental feedback, while others will receive control (sham or yoked) feedback.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your food craving and eating behavior will be assessed at Week 1 and Week 7. Your brain's craving network strength will be measured at Week 1 and Week 3.

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NCT06426693

Craving Network Neurofeedback

Recruiting
NAAges 18–60InterventionalTreatment
Yale University
~50 participants
Updated 2025-12-03 on ClinicalTrials.gov
What's tested:Experimental feedbackControl feedback

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in craving network strength during transfer runs
Measured over Week 1 and 3
+5 more outcomes measured
Overweight or Obesity
1 sites across 1 states
Connecticut1
  • Kathleen A Garrison, PhD · PRINCIPAL_INVESTIGATOR · Yale University

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Eligibility criteria

Inclusion

Ages 18 to 60 years
Body mass index \>25 kg/m2
\>2.37 Food Craving Inventory score

Exclusion

Current or past 6 months use of anti-obesity medications
Weight-reduced state defined as \>10% weight reduction in the past 6 months.
Nicotine use
Current diagnosis of neurological or psychiatric disorder
Obesity-related diseases such as type-2 diabetes
Contraindications to MRI
Baseline scanning with motion \>0.15mm frame to frame displacement.
  • Change in craving network strength during transfer runsWeek 1 and 3

    Craving network strength will be measured during transfer (i.e., no feedback) runs and compared across scan sessions.

  • Change in Food Craving Inventory Mean ScoreWeek 1, Week 7

    Food Craving Inventory has 28 items rated 1-5 and overall mean is calculated, range 1-5 with higher score indicating higher craving. FCI will be compared between baseline and 1 month follow-up.

  • Change in Automated Self-Administered 24-hour (ASA24®) Dietary Assessment Tool Healthy Eating Index (HEI).Week 1, Week 7

    ASA-24 HEI is scored 0-100 with 100 indicating healthier diet and composite scores examined to interpret the overall score. HEI will be compared between baseline and 1 month follow-up.

  • Change in craving network strength during resting state runsWeek 1 and 3

    Craving network strength will be measured during resting state runs and compared across scan sessions.

  • Change in Food Rating Task healthiness, tastiness, and choice scoresWeek 1, Week 7

    Food Rating Task outcomes include healthiness, tastiness, and choice. Healthiness and tastiness mean score is taken, range 1-5, with 5 indicating higher healthiness or tastiness. Choice is counted from 0-48 items choosing the food item over the neutral reference food item, with higher values indicating more frequent choice. Food Ratings will be compared between baseline and 1 month follow-up.

  • Change in Food Snack Task caloric intakeWeek 1 and 3

    Food Snack Task will be used to measure caloric intake (out of a maximum value to calories offered) and compared across scan sessions.