This study is looking at whether a medication called tranexamic acid (TXA) can help reduce blood loss and the need for blood transfusions during and after breast reconstruction surgery using your own tissue (free flap). TXA is a drug that helps blood clot. We know it helps in other surgeries, but we need more information for breast free flap surgery. You may be able to join if you are an adult woman having this type of breast reconstruction at UVA Medical Center. You cannot join if you are allergic to TXA or have certain medical conditions like a history of blood clots. The study will measure changes in your hemoglobin (a protein in red blood cells) one day after surgery and how many people need a blood transfusion up to 72 hours after surgery. The current status of this study is unclear.

Study design

This is an interventional study planning to enroll 100 women. Participants will be randomly assigned to receive either tranexamic acid or a placebo (saline) during surgery.

What's involved

Participants will receive either tranexamic acid or saline intravenously during their surgery. Blood tests will be taken to measure hemoglobin one day after surgery.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for at least one day after surgery for hemoglobin levels, and up to 72 hours for transfusion rates.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.