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Fractionated Laser Resurfacing for Actinic Keratoses and Skin Cancer Prevention

This study is investigating if Fractionated Laser Resurfacing (FLR), a rejuvenating laser that makes tiny holes in the skin, can prevent precancerous growths called actinic keratoses (AKs) and non-melanoma skin cancers. Researchers want to see if treating one forearm/wrist with FLR can protect it from these skin conditions in older adults. You might be able to join if you are 60 or older, have fair skin, and have 5 to 10 AKs on each forearm/wrist. The study will measure changes in the number of AKs and skin cancers over up to 5 years. The study is also exploring if photographs can predict where AKs and skin cancers will form. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 80 participants. It is testing Fractionated Laser Resurfacing.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for changes in actinic keratosis and non-melanoma skin cancers for up to 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06428721

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Recruiting
NAAges 60+InterventionalPrevention
Wright State University
~80 participants
Updated 2026-07-16 on ClinicalTrials.gov
What's tested:Fractionated Laser Resurfacing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline in the number of actinic keratosis due to FLR treatment.
Measured over Up to 5 years
+1 more outcome measured

Conditions

Actinic Keratoses
Aging
Non-Melanoma Skin Cancer

Explore related trials

Actinic KeratosisSkin Carcinoma

NCT06428721

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Wright State Physicians

    Fairborn, Ohiostudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jeffrey Travers, MD, PhD · PRINCIPAL_INVESTIGATOR · Wright State University

Who to contact

Manager, Clinical Research Operations
[email protected]
937-245-7500
Email the study team

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Eligibility criteria

Inclusion

Adult Males and Females aged 60 and older
Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring
Skin type fair (Fitzpatrick I-II)
Females must be post-menopausal and not be on systemic hormone replacement therapy
Able to comprehend procedures and risks

Exclusion

More than 10 AKs on an extremity
AKs that are large (2-3+, hyperkeratotic grade 3 lesions)
AKs that are very thick (\>3 mm)
Medical history of diabetes
History of poor wound healing or scarring
Large tattoos that can interfere with study
Other serious health issues and other skin diseases that could interfere with the study
Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists.
Planning to leave region in next 5 years
Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.

What this trial measures

  • Change from baseline in the number of actinic keratosis due to FLR treatment.Up to 5 years

    Investigator will assess the number of actinic keratosis on both forearms at each visit.

  • Change from baseline in the number of non-melanoma skin cancers due to FLR treatment.Up to 5 years

    Investigator will assess the number of actinic keratosis on both forearms at each visit.