Feasibility Trial of Empagliflozin for Pediatric Chronic Kidney Disease

This study is looking into whether it's possible to conduct a clinical trial for young people (ages 12-25) with chronic kidney disease (CKD). We want to see if 40 youth with CKD can be successfully enrolled in a trial using Empagliflozin, a medication already approved for adults with CKD. We also want to explore if taking Empagliflozin for three months can improve test results related to kidney and heart health. You would be randomly assigned to either receive Empagliflozin or continue with your usual care. We are looking for participants with Stage 3-4 CKD, but cannot include individuals with certain conditions like heart disease, diabetes, or a history of organ transplant.

Study design
This is an interventional study planning to enroll 40 participants. Participants will be randomly selected to either receive Empagliflozin or continue with their usual care.
What's involved
Participants will take Empagliflozin or continue usual care for 3 months. The study will measure whether participants complete all study procedures over 4 years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 4 years to assess completion of study procedures.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06430684

Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease

Recruiting
EARLY_PHASE1Ages 12–25InterventionalTreatment
Ann & Robert H Lurie Children's Hospital of Chicago
~40 participants
Updated 2026-08-19 on ClinicalTrials.gov
What's tested:Empagliflozin 10 MG

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants who complete all study procedures
Measured over 4 years
Chronic Kidney Diseases
Pediatric Kidney Disease

NCT06430684

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Ann & Robert H. Lurie Children's Hospital of Chicago

    Chicago, Illinoisstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

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Eligibility criteria

Inclusion

Stage 3-4 CKD; estimated GFR using CKiD U25-creatinine equation 20-60mL/min/1.73m2

Exclusion

Heart Disease
Diabetes
Pregnancy
Recipient of solid organ transplant
history of chemotherapy or stem cell transplant
moderate to severe persistent asthma
liver disease
class 2 or greater obesity
inability to follow study procedures due to cognitive impairment
obstructive uropathy or requirement for intermittent urinary catheterization
systolic blood pressure \<100mgHg
orthostatic hypotension
current use of an SGLT2i
anticipated need for titration of anti-hypertensives within 3 months
active use of any immunosuppressive medications
lack of clearance by primary nephrologist for participation
  • Percentage of participants who complete all study procedures4 years

    Compared to the number recruited, how many participants complete the study