Understanding Blood Clot Risk in Newborns with Congenital Heart Disease
This observational study aims to understand why newborns with severe congenital heart disease (CHD) are at higher risk for blood clots after heart surgery. Researchers will collect discarded blood samples from ten neonates (newborns) at Boston Children's Hospital who are undergoing surgery in their first week of life. The goal is to characterize microRNA (tiny molecules that help control gene activity) in these blood samples to learn more about the molecular mechanisms that lead to abnormal clotting. This study is for newborns aged 1 to 7 days with severe CHD who are having surgery, and there are no exclusion criteria. The main goal is to understand the microRNA profile in these blood samples within two days of collection.
- Study design
- This is an observational study involving 10 neonates. It is not a treatment study but rather focuses on understanding a medical condition.
- What's involved
- Participation involves collecting discarded blood samples from routine clinical labs before and after surgery. No additional procedures are required.
- Compensation
- Not stated in the trial record.
- Follow-up
- MicroRNA will be measured in blood samples at 2 days after collection.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
At a glance
Conditions
NCT06434207
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Boston Children's Hospital
Boston, Massachusettsstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Who to contact
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Inclusion
Exclusion
What this trial measures
- Characterization of microRNA in whole blood samples from neonates2 days
isolation, purification and sequencing of patterns of miRNA and clustering analysis will be performed to determine predominant populations of miRNA related to inflammation, complement activation, and coagulation among other pathways