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Observational Study on Kidney Stones, Insulin Resistance, and Inflammation

This study is looking at the connections between kidney stones, insulin resistance (when your body doesn't use insulin properly), and inflammation. Researchers believe that people who form calcium kidney stones and have insulin resistance might have more inflammation due to higher levels of visceral fat (fat around your organs). The study will compare visceral fat and inflammation markers in 20 people who have had calcium kidney stones (but not diabetes) and 20 healthy people who have never had kidney stones. All participants will visit the University of Chicago Medicine for a DEXA scan (to measure body fat) and to provide blood and urine samples. The study's status is currently unclear.

Study design
This is an observational study with 40 participants. It will compare two groups: those with calcium kidney stones and healthy controls.
What's involved
You would stop certain supplements and diuretics for one week, and complete a 24-hour urine collection and food questionnaire at home. Then, you'd have a half-day visit to the research center for blood and urine samples, blood pressure, body measurements, a DEXA scan, and a brief health history.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken during a one-week total period, with one half-day visit to the research center.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06436235

Kidney Stone Inflammation

Recruiting
Not specifiedAges 18–70Observational
University of Chicago
~40 participants
Updated 2026-07-08 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference in visceral fat content in participants who form kidney stones with insulin resistance compared to participants who form kidney stones without insulin resistance and controls
Measured over 1 week total, one half day in the CRC
+1 more outcome measured

Conditions

Kidney Stone
Stone, Kidney

Explore related trials

Nephrolithiasis

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Megan Prochaska, MD · PRINCIPAL_INVESTIGATOR · University of Chicago

Who to contact

Megan Prochaska, MD
[email protected]
773-702-1000 · ext. 45488
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Stone formers:
Age 18-70
History of at least one calcium-based kidney stone
Healthy Controls:
Age 18-70
No history of kidney stone or family history of kidney stones

Exclusion

History of primarily uric acid
Cysteine, or struvite stones
History of diabetes or impaired glucose tolerance
Previous thiazide use
Anyone on a medication that cannot be stopped that may affect urine composition
Previous bariatric surgery or ileostomy
Primary hyperparathyroidism and elevated serum calcium.

What this trial measures

  • Difference in visceral fat content in participants who form kidney stones with insulin resistance compared to participants who form kidney stones without insulin resistance and controls1 week total, one half day in the CRC

    Levels of visceral fat as measured by dual x-ray absorptiometry (DEXA).

  • Difference in inflammatory markers between participants who form kidney stones and controls1 week total, one half day in the CRC

    Markers of systemic inflammation, including high-sensitivity CRP, interleukin-6, MMP-7, MMP-9, TNF-alpha, and endotrophin.