Study of MRI and CT-Guided Radiation for Abdominopelvic Sarcomas

This study is looking at a new way to give radiation treatment for abdominopelvic sarcomas (cancers in the belly or pelvis). It uses Magnetic Resonance Image (MRI) and Computed Tomography (CT) scans to guide Stereotactic Body Radiation Therapy (SBRT). This helps make sure the radiation goes to the tumor and not healthy organs. You might be able to join if you are 12 years or older, have a sarcoma in your belly or pelvis that can be removed by surgery, and are generally in good health. The main goal is to see how much radiation side effects (morbidity) people have after 2 years. The study is currently unclear about its status and plans to enroll 20 participants.

Study design
This is an interventional study with no specified phase, planning to enroll 20 participants. It is a single-arm study, meaning all participants receive the same intervention.
What's involved
You would receive radiation treatment daily for 5 consecutive days, excluding weekends and holidays. Within 12 weeks of finishing radiation, you would have surgery to remove the tumor.
Compensation
Not stated in the trial record.
Follow-up
You would be followed by the radiation oncology team for 5 years after completing radiation therapy.

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NCT06436612

Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)

Recruiting
PHASE2Ages 12+InterventionalTreatment
Jonsson Comprehensive Cancer Center
~20 participants
Updated 2026-06-05 on ClinicalTrials.gov
What's tested:Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Radiation morbidity at 2 years
Measured over At 2 years
Abdominopelvic Sarcomas
1 sites across 1 states
California1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Histologically confirmed sarcoma
Primary or recurrent disease involving the abdomen or pelvis
Resectable primary lesion
Age ≥ 12 years old
Karnofsky performance status (KPS) ≥ 70 or Eastern Cooperative Oncology Group (ECOG) 0-2
If a woman is of childbearing potential, a negative serum or urine pregnancy test must be documented

Exclusion

Active treatment of a separate malignancy
History of prior irradiation to the area targeted for treatment
  • Radiation morbidity at 2 yearsAt 2 years

    Evaluate the 2 year rate of grade ≥2 radiation morbidity, according to Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0.