SuperSaturated Oxygen Comprehensive Observational Registry for Heart Attack Patients
This study, called the SuperSaturated Oxygen Comprehensive Observational Registry (SSCORE), is looking at how SuperSaturated Oxygen (SSO2) Therapy affects patients who have had a severe type of heart attack called an ST-Elevation Myocardial Infarction (STEMI) or Acute Myocardial Infarction (AMI). Researchers want to see if SSO2 Therapy can reduce the size of the damaged heart muscle and improve patients' quality of life, compared to standard care. They will also look at the costs involved. You might be able to join if you are between 18 and 80 years old, have had an AMI, and your blocked artery was successfully opened with a procedure called PCI. The study is currently collecting information, but its exact status is unclear.
- Study design
- This is an observational study aiming to enroll 1000 participants. It compares patients who receive SSO2 Therapy with those receiving usual care.
- What's involved
- You will complete quality of life questionnaires (KCCQ and Eq5D). A subset of patients will also have a cardiac MRI.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your health will be followed for heart-related events or heart failure burden for a median of 1.5 years. Infarct size will be measured 2-7 days after your PCI procedure.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
SuperSaturated Oxygen Comprehensive Observational Registry
At a glance
Conditions
Where it's being run
25 sites across 10 statesStudy leadership
- William W O'Neill, MD · PRINCIPAL_INVESTIGATOR · Henry Ford Hospital
Who to contact
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What this trial measures
- Cardiovascular (CV) death or Heart Failure (HF) burdenMedian of 1.5years
The clinical outcome will be a non-hierarchical composite measured during a median follow-up of 1.5 years (minimum of 1 year and maximum of 2 years). The composite will be analyzed as the time-to-first occurrence of CV death or HF event, defined as new/worsening HF requiring hospitalization or outpatient treatment.
- Infarct Size2-7 days after PCI
Cardiac magnetic resonance imaging will be used to measure the co-primary endpoint of infarct size within 2-7 days after PCI in a subset of patients.