Studying Dronabinol's Effects on Alcohol and Cannabis Use
This study is looking at how Dronabinol (a pill form of THC) affects alcohol consumption and brain activity related to rewards in people who use both alcohol and cannabis. Researchers want to understand the brain mechanisms behind using both substances. You might be able to join if you are between 21 and 40 years old, drink alcohol, and use cannabis. The study will compare Dronabinol (20 mg) to a placebo (an inactive pill). The main goals are to see how brain activity changes when you see alcohol or cannabis cues, and how much alcohol you choose to drink after taking the study medication. The current status of this study is unclear.
- Study design
- This interventional study plans to enroll 28 participants. It will compare Dronabinol to a placebo.
- What's involved
- You will have a screening, a baseline visit, and two lab visits. These lab visits will include an MRI scan and an opportunity to drink alcohol, with visits separated by 7 to 14 days.
- Compensation
- Not stated in the trial record.
- Follow-up
- Brain activation and alcohol self-administration will be measured at 1 hour and 3-4 hours after medication on days 7 and 14.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in alcohol cue-elicited brain activation (fMRI) between medication periods1 hour after administration of a single dose of study medication at 7 days, 14 days.
Alcohol cue reactivity task BOLD signal to alcohol cues, relative to neutral beverage cues
- Change in cannabis cue-elicited brain activation (fMRI) between medication periods1 hour after administration of a single dose of study medication at 7 days, 14 days.
Cannabis cue reactivity task BOLD signal to cannabis cues, relative to neutral cues
- Alcohol self-administration3-4 hours after administration of a single dose of study medication at 7 days, 14 days.
Number of drinks self-administered
- Self-reported alcoholic drinks consumedone report per day for the 14 days after the final laboratory visit on day 14.
\# of drinks consumed per day
- Self-reported cannabis useOne report per day for the 14 days after the final laboratory visit on day 14
Amount of cannabis consumed per day
- Self-reported cannabis and alcohol co-useOne report per day for the 14 days after the final laboratory visit on day 14.
Number of days in which cannabis and alcohol were both used