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Mindfulness-based Neurofeedback for Borderline Personality Disorder

This study is testing if mindfulness-based neurofeedback (mbNF) can improve the benefits of psychotherapy for adults with Borderline Personality Disorder (BPD). You would participate in one session of either mindfulness-based neurofeedback or a control neurofeedback, followed by 20 weeks of online group therapy. Researchers will look at changes in your brain's resting state functional connectivity immediately after the neurofeedback session to see if the intervention is successful. The study aims to enroll 150 participants and is currently recruiting.

Study design
This is an interventional study with 150 planned participants. It compares mindfulness-based neurofeedback to a control neurofeedback.
What's involved
You would complete one neurofeedback session and then participate in 20 weeks of remote online weekly DBT skills group. You would also need to keep any prescribed medications and psychotherapy constant during the study.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured immediately after the neurofeedback session on the same day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06446765

Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder

Recruiting
PHASE2Ages 18–60InterventionalTreatment
Yale University
~150 participants
Updated 2026-06-09 on ClinicalTrials.gov
What's tested:mindfulness-based Neurofeedbackcontrol Neurofeedback

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in within-Default Mode Network (DMN) resting state functional connectivity after one session of neurofeedback (NF)
Measured over From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day
+1 more outcome measured

Conditions

Borderline Personality Disorder

Explore related trials

Borderline Personality Disorder

Where it's being run

1 sites across 1 states
Connecticut1

Study leadership

  • Sarah K Fineberg, MD PhD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Sarah K Fineberg, MD PhD
[email protected]
203-974-7265
Email the study team

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Eligibility criteria

Inclusion

age 18-60,
be able to provide written informed consent,
meet criteria for BPD on semi-structured clinical interview,
able to plan to keep any prescribed medications and psychotherapy constant during the study
fluent in English.

Exclusion

current DBT psychotherapy outside the study
lifetime primary psychotic disorder
manic episode in the last one year
developmental disorder (e.g. autism)
history of learning disorder
severe substance use disorder in the last 3 months
active suicidal ideation with intent or plan in the past 3 months
history of major medical or neurologic disorder
MRI contraindications, including pregnancy
poor performance on reading task (WRAT \> 11 errors)
newly prescribed medications in the past 8 weeks
daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics)
any scheduled daily benzodiazepines
change in psychotherapy type or frequency in the past 12 weeks.
At the discretion of the study PI

What this trial measures

  • Change in within-Default Mode Network (DMN) resting state functional connectivity after one session of neurofeedback (NF)From baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day

    Defined as within-DMN connectivity as the resting state seed-based connectivity between core nodes of medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). Change = post-NF within-DMN connectivity - pre-NF within-DMN connectivity.

  • Change in DMN-Frontoparietal Control Network (FPCN) anticorrelation in resting state functional connectivity data after one session of neurofeedbackFrom baseline (immediately before neurofeedback) to immediately after neurofeedback on the same day

    Defined as DMN-FPCN anticorrelation as the fMRI seed-based connectivity from mPFC to dorsolateral prefrontal cortex (dlPFC)). Change = post-NF mPFC-dlPFC anticorrelation - pre-NF mPFC-dlPFC anticorrelation