Platelet-Rich Plasma Injections for Knee Osteoarthritis
This study is testing Platelet-Rich Plasma (PRP) injections for knee osteoarthritis (OA), a condition causing joint pain and stiffness. Researchers want to understand how PRP works by looking at protein changes in your blood after injections. You might be eligible if you are 18-70 years old, have mild to moderate knee OA symptoms for at least three months, and can attend physical therapy. About 60 people will participate, receiving either PRP or a control saline injection. The study aims to discover the benefits of PRP for knee OA and how to best achieve those effects. The current recruitment status is unclear.
- Study design
- This is a randomized, double-blind, placebo-controlled study with about 60 participants, split into two age groups. All participants will eventually receive a PRP injection through a crossover phase.
- What's involved
- You will have blood drawn before and after injections, with visits at Week 0, Week 2, Week 12, and possibly Week 14. You will receive either a Platelet-Rich Plasma (PRP) injection or a control saline injection into your knee.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint for measuring protein changes is at 2 weeks, with follow-up visits extending to 12 weeks and an optional 14-week visit for some participants.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Platelet Rich Plasma Injections In Young And Old Human Subjects
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Anthony Luke, MD, MPH · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
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What this trial measures
- Identify Protein Changes in Platelet Rich Plasma (PRP)2 weeks
The protein changes from a single autologous PRP injection (5 mL) vs normal saline control, using proteomic analysis of' venous blood samples. For proteomic analysis of Platelet poor plasma (PPP) and PRP, the samples will undergo quantitative mass spectrometry, with higher numbers indicating more proteins and lower numbers meaning less proteins.