Phase 1b Study of VERVE-201 for Refractory Hyperlipidemia

This study is testing a new treatment called VERVE-201 for people with refractory hyperlipidemia (very high cholesterol and triglycerides that haven't responded to other treatments). VERVE-201 is given as an intravenous (IV) infusion and uses a special technology to help lower your cholesterol and triglycerides. The main goal of this study is to see how safe VERVE-201 is and to understand its effects on your body. You may be able to join if you are between 18 and 70 years old and have refractory hypercholesterolemia or hypertriglyceridemia. We are looking for 36 participants in total. The current recruitment status is unclear.

Study design
This is an open-label, Phase 1b study, meaning both you and the study team will know you are receiving VERVE-201. It will involve a single dose of VERVE-201 and plans to enroll 36 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
You will be followed for up to 365 days after receiving the treatment to monitor for side effects.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06451770

Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

Recruiting
PHASE1Ages 18–70InterventionalTreatment
Verve Therapeutics, Inc.
~36 participants
Updated 2026-07-17 on ClinicalTrials.gov
What's tested:VERVE-201

At a glance

Recruiting sites
16 of 16 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs)
Measured over Up to Day 365
Hypercholesterolemia
Hypertriglyceridemia
Refractory Hyperlipidemia

NCT06451770

Where you'd take part

This study runs at 16 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Clinical Study Center

    Clearwater, Floridano site contact published

    Recruiting

  • Clinical Study Center

    Miami Lakes, Floridano site contact published

    Recruiting

  • Clinical Study Center

    Port Orange, Floridano site contact published

    Recruiting

  • Clinical Study Center

    New York, New Yorkno site contact published

    Recruiting

  • Clinical Study Center

    Adelaide, Australiano site contact published

    Recruiting

  • Clinical Study Center

    Melbourne, Australiano site contact published

    Recruiting

  • Clinical Study Center

    Chicoutimi, Canadano site contact published

    Recruiting

  • Clinical Study Center

    Montreal, Canadano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Email the study team

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Eligibility criteria

Inclusion

Refractory hypercholesterolemia
Refractory hypertriglyceridemia

Exclusion

Active or history of chronic liver disease
Current treatment with monoclonal antibody targeting ANGPTL3 or prior treatment within specified timeframe
Clinically significant or abnormal laboratory values as defined by the protocol
  • Incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs)Up to Day 365