This study is looking at a treatment called low-intensity focused ultrasound (LIFU) for people who have opioid use disorder, chronic back pain, and anxiety. LIFU uses sound waves to gently change brain activity in a specific area called the anterior insula (AI), which is thought to play a role in pain, addiction, and anxiety. The main goals are to see if LIFU is safe and well-tolerated, and if it can help reduce pain, anxiety, and cravings for opioids. You might be able to join if you are 18-75 years old, have chronic back pain for at least three months, and show signs of central sensitization (a condition where your nervous system becomes over-sensitive to pain). The study plans to enroll 25 participants, but its current recruitment status is unclear.

Study design

This is an interventional study, meaning participants will receive a specific treatment. It will compare LIFU to a sham (inactive) treatment in 25 participants.

What's involved

Participants will have an MRI scan, neurological assessments, and clinical assessments. They will receive one session of LIFU or sham treatment.

Compensation

Not stated in the trial record.

Follow-up

Safety will be measured immediately before and within one hour after the LIFU or sham session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.