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Magnesium for Neuroprotection After Cardiac Arrest

This study is looking at whether magnesium sulfate can help protect the brain after a cardiac arrest (when the heart stops beating) and return of spontaneous circulation (ROSC, when the heart starts beating again). You might be able to join if you are between 18 and 85 years old and have experienced a cardiac arrest with ROSC within the last two hours. Researchers want to see if it's safe and possible to give magnesium sulfate or a saline (saltwater) placebo within two hours of ROSC. The main goals are to check how well the study can be run and to gather early information for a larger future study. This study is currently unclear on its recruitment status and plans to enroll 178 participants.

Study design
This is an interventional study with 178 planned participants. It compares magnesium sulfate to saline.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed through study completion, which is an average of 90 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06455514

Post-CA Neuroprotection With Magnesium

Recruiting
PHASE1Ages 18–85InterventionalPrevention
NYU Langone Health
~178 participants
Updated 2026-04-07 on ClinicalTrials.gov
What's tested:Magnesium SulfateSaline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of cases where successful randomization occurred
Measured over Through study completion, an average of 90 days
+6 more outcomes measured

Conditions

Cardiac Arrest
Return of Spontaneous Circulation

Explore related trials

Cardiac Arrest

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Sam Parnia · PRINCIPAL_INVESTIGATOR · NYU Langone Health

Who to contact

Anelly Gonzales
[email protected]
646-501-6923
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved \<2 hours prior to recruitment

Exclusion

Age \< 18 years or \> 85 years
Traumatic cardiac arrests
Unsustained ROSC (\<20 minutes)
Patient who is responsive/able to follow motor commands within 1 hour of achieving ROSC
Plan for withdrawal of life support within 72 hours of ROSC
Known pregnant women at the time of the cardiac arrest
Known prisoners at the time of the cardiac arrest
Subjects who have a medical o social condition that would make them inappropriate for the study based on the PI's or clinical team judgement.

What this trial measures

  • Proportion of cases where successful randomization occurredThrough study completion, an average of 90 days
  • Proportion of cases where Magnesium (Mg) or saline bolus was delivered with a goal of <2 h after return of spontaneous circulation (ROSC)Through study completion, an average of 90 days
  • Proportion of cases with adherence to treatment protocolThrough study completion, an average of 90 days

    Assessment of adherence will involve reviewing chart data to evaluate the timing of medication order placement and timing of administration by the nurse.

  • Proportion of cases for which serum is successfully drawn and analyzedThrough study completion, an average of 90 days
  • Proportion of cases where patient's Cerebral Performance Category Score (CPC) status is assessedAt hospital discharge, on average 3 weeks

    The CPC assessment score will be derived from the patient's electronic medical record (EMR).

  • Proportion of cases where patient's CPC status is assessedDay 30

    The CPC assessment score will be derived from the patient's EMR.

  • Proportion of cases where patient's CPC status is assessedDay 90

    The CPC assessment score will be derived from the patient's EMR.