Daily Eating Patterns for Total Health Study

This study, called DEPTH, is looking at how the timing of your meals affects weight loss over 12 months for people with obesity. You would follow a reduced-calorie, low-fat diet, aim for over 200 minutes of physical activity weekly, and receive behavioral support. Some participants will also have goals to eat most of their calories in the morning, while others will eat most in the evening. Researchers want to see if these time-based eating patterns help with long-term weight loss and how they affect appetite. The study plans to enroll 174 participants aged 25 to 60 with a BMI between 27 and 45. The current recruitment status is unclear.

Study design
This is an interventional, randomized controlled trial planning to enroll 174 participants. Participants will be assigned to one of three groups: morning-loaded eating, evening-loaded eating, or a standard approach.
What's involved
Participants will follow a specific diet and exercise plan for 12 months. Weight and Body Mass Index (BMI) will be measured at 0, 3, 6, and 12 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months, with primary endpoints measured at 0, 3, 6, and 12 months.

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NCT06455995

Daily Eating Patterns for Total Health Study

Recruiting
NAAges 25–60InterventionalTreatment
The University of Tennessee, Knoxville
~174 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:DEPTHDEPTH-MorningDEPTH-Evening

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent Weight Change
Measured over 0, 3, 6, and 12 months
+1 more outcome measured
Obesity
1 sites across 1 states
Tennessee1

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Eligibility criteria

Inclusion

Body mass index (BMI) between 27 and 45 kg/m2.

Exclusion

Report not regularly (\>/= 5 days/wk) consuming energy (\>/= 100 kcal) prior to 12 pm, and not being able to consume energy every day (\>/= 50 kcal) within one hour of awakening.
Report taking sleep medication or not regularly (\>/= 5 nights/wk) getting at least 6 hrs of total sleep.
Report being a shift workers/alternative shift workers that work outside of 7 am and 7 pm.
Report being diagnosed with type 1, or type 2 diabetes and taking medication that requires eating to occur at certain time periods.
Report a heart condition, chest pain during periods of activity or rest, or loss of consciousness on the Physical Activity Readiness Questionnaire (PAR-Q). Individuals reporting joint problems, prescription medication usage, or other medical conditions that could limit exercise will be required to obtain written physician consent to participate.
Report being unable to walk for 2 blocks (1/4 mile) without stopping.
Report major psychiatric diseases or organic brain syndromes.
Report currently participating in a weight loss program and/or taking weight loss or appetite regulation medication or lost \>/= 5% of body weight during the past 6 months.
Report having bariatric surgery for weight loss/planning to have bariatric surgery in the next 12 months.
Report being pregnant, lactating, \< 6 months post-partum or plan to become pregnant (next 12 months).
Report planning to move outside of the metropolitan area within the time frame of the investigation.
Do not have daily access to PC with internet or smartphones (needed for self-monitoring).
  • Percent Weight Change0, 3, 6, and 12 months

    Percent change in weight (weight change in lbs at follow up / baseline weight in lbs)

  • Body Mass Index (BMI)0, 3, 6, and 12 months

    Change in BMI calculated as weight in kg / height in m2