Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
This study aims to understand how the brain plans and controls movement for speech, and how it hears and understands speech, in healthy adults and people who have had a cerebellar stroke. Researchers will use special brain imaging techniques (fMRI and EEG) to look at brain activity while you listen to and produce speech. They want to find out which brain areas are involved in speech, how these areas help detect and correct speech errors, and what role the cerebellum (a part of the brain at the back of your head) plays. The study involves several behavioral tasks and non-invasive brain imaging sessions.
- Study design
- This interventional study plans to enroll 100 participants, including healthy adults and individuals with cerebellar stroke, to understand brain activity related to speech.
- What's involved
- You would complete up to 6 sessions, each lasting 2-3 hours, within 12 months of joining. These sessions involve hearing assessments, behavioral speech tasks, and non-invasive brain imaging using EEG and fMRI.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your brain responses will be measured during one session lasting 2-3 hours, within 12 months of enrollment.
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Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
At a glance
Conditions
NCT06458153
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Pittsburgh
Pittsburgh, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jason W Bohland, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Pittsburgh
Who to contact
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Inclusion
Exclusion
What this trial measures
- Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speechOne session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for the LISTEN-SELF vs. PRODUCE and LISTEN-OTHER vs. PRODUCE conditions. Encoding models will predict activity in regions-of-interest (ROIs) based on a set of speech features.
- BOLD responses related to pre-speech auditory modulationOne session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses to auditory stimuli across conditions (e.g., SPEAK, REHEARSE, PLAN, SILENT).
- EEG responses to self vs. externally generated speechOne session lasting 2-3 hours, within 12 months of enrollment
The dependent variables are evoked responses, aligned to sound onset, measured with EEG during task performance. We will contrast evoked responses across conditions (e.g., TALK, LISTEN).
- BOLD responses to induced auditory errorsOne session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will determine activations in regions of interest that correlate with applied perturbations during speech. We will also compare SPEAK vs. LISTEN activations in perturbed and unperturbed conditions.
- BOLD responses during adaptation to auditory perturbationsOne session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during the HOLD and BASELINE phases of the adaptation paradigm. We will determine areas where activation is associated with changes in formant frequencies in early and late windows in speech recordings.
- BOLD responses during learning of non-speech auditory motor targetsOne session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during PRESS trials across runs. We will contrast LISTEN vs. PRESS trials to measure motor induced sensory modulation.