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ProAgio and Gemcitabine for Metastatic Triple Negative Breast Cancer

This study is testing a new combination of two drugs, ProAgio and gemcitabine, for people with metastatic triple negative breast cancer (cancer that has spread and doesn't have certain receptors). You might be able to join if you are 18 or older, have this type of breast cancer, and have already received at least two other treatments. The study aims to understand how safe and effective this drug combination is. Researchers will be looking at the results for up to two years to see how well the treatment works. Your cancer must be HER2 negative, ER negative, and PR negative to be eligible.

Study design
This is a single-arm, Phase I/II study, meaning all participants will receive the study treatment. It plans to enroll up to 51 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to two years after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06460298

ProAgio in Combination With Gemcitabine in Patients With Metastatic Triple Negative Breast Cancer

Recruiting
PHASE1Ages 18+InterventionalTreatment
ProDa BioTech, LLC
~51 participants
Updated 2026-08-31 on ClinicalTrials.gov
What's tested:ProAgio Dose Levels (DL) 1,2,3,4ProAgio Dose Expansion

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Part 1 (Dose Escalation)
Measured over 2 Years
+1 more outcome measured

Conditions

Triple Negative Breast Cancer

Explore related trials

Triple-negative breast cancer

NCT06460298

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Winship Cancer Institute of Emory University

    Atlanta, Georgiastudy coordinator listed

    Not yet recruiting

  • Emory University Winship Cancer Institute

    Atlanta, Georgiano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Kevin Kalinsky, M.D, M.S · PRINCIPAL_INVESTIGATOR · Emory University Winship Cancer Institute

Who to contact

Damon Michaels
[email protected]
615-614-1185
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Adult participants, ≥ 18 years of age, with histologically or cytologically confirmed metastatic breast cancer that is estrogen receptor (ER) negative (less than 10%), progesterone receptor (PR) negative (less than 10%), and HER2 negative/unamplified as per ASCO/CAP guidelines (Wolff et al., 2018). If ER/PR less than 10%, prior endocrine therapy is permitted, and the participant is not considered appropriate for hormone based therapy. Participants must agree to provide archival tumor material from metastatic site (most recent archival tumor tissue immediately prior to enrollment is strongly preferred) and must agree to undergo research tumor biopsy before treatment and during cycle 2 at the same site of metastatic disease, if presence of easily accessible lesion, at the discretion of the treating physician.
Participants must have received at least two lines of prior systemic treatment for advanced disease. If participants received systemic therapy in the operable setting and the tumor progressed within 12 months of the receipt of the last dose of systemic therapy, this will be considered one line of prior systemic therapy for advance disease. Participants must be more than 14 days removed from most recent standard of care or experimental drug treatment for their tumor.
ECOG performance status ≤2
Participants must have adequate organ and marrow function as defined below:
Absolute neutrophil count ≥1,500/mcL
Hemoglobin ≥9 g/ dL (recent transfusion allowed)
Platelets ≥100,000/mcL
AST(SGOT)/ALT(SGPT) ≤3 x ULN. AST and ALT (up to 5x ULN is permitted for participants with liver metastases)
Total bilirubin ≤1.5 x institutional ULN
Creatinine clearance ≥60 mL/min (measured using Cockcroft- Gault equation or the estimated glomerular filtration rate)
Participants with CNS metastases must be treated and/or stable (no progression for at least 4 weeks after local prior therapy as ascertained by clinical examination and brain imaging (MRI or CT) during the screening period). Those with symptoms suggestive of possible CNS metastases (such as new headaches) must undergo brain MRI as part of screening.
Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial.
The effects of ProAgio on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and for the 6 months following the last dosing of study drug. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
During dose escalation, participants with bone only and/or non-measurable disease are eligible. During dose expansion, only participants with measurable disease are eligible.
Ability of subject to understand and the willingness to sign a written informed consent document.

Exclusion

Participants who have had prior treatment with gemcitabine in the metastatic setting.
Platelet transfusion within 7 days prior to treatment start.
Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better. Patients with history of known congestive heart failure (left ventricular ejection fraction (LVEF) \<50%) must have documented LVEF \>50% within 12 months of study enrollment.
Prolonged QTc interval \>480 msec on screening EKG
Participants with known diagnosis of a chronic neurologic disorders (such as multiple sclerosis, Huntington's disease, Parkinson's disease, or uncontrolled epilepsy) which causes motor disturbance, visual disturbance, or seizure and could confound assessment of neurologic toxicity caused by the study drug.
Pregnant or nursing women are excluded from this study because ProAgio is an agent with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with ProAgio, breastfeeding should be discontinued if the mother is treated with ProAgio.
Participants who have undergone a major surgical procedure (within \< 28 days) are excluded.
Participants with uncontrolled bleeding episodes \<28 days prior to enrollment are excluded.

What this trial measures

  • Part 1 (Dose Escalation)2 Years

    To identify the maximum tolerated dose (MTD) of ProAgio in combination with gemcitabine in patients with metastatic TNBC who have been previously treated with at least two prior lines of therapy.

  • Part 2 (Dose Expansion)2 Years

    To estimate the objective response rate (ORR) of ProAgio in combination with gemcitabine in patients with metastatic TNBC who have been previously treated with at least two prior lines of therapy.