NCT06462521
Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection
Enrolling by Invitation
NAAges 18+InterventionalPreventionIndiana UniversityInvestigator-initiated
~570 participants
Updated 2025-12-30 on ClinicalTrials.gov
What's tested:Cold Snare Piecemeal Resection (CSPR)Cold Snare Endoscopic Mucosal Resection (Cold EMR)
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Efficacy of Resection (Central Post-Resection Biopsies)
Measured over 1 day
+1 more outcome measured
Conditions
Where it's being run
1 sites across 1 statesIndiana1
Study leadership
- John J Guardiola, MD · PRINCIPAL_INVESTIGATOR · Indiana University
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
a sessile serrated lesion or hyperplastic polyp ≥ 10 mm during procedure (Serrated Cohort) or
a 10-19 mm conventional adenoma during procedure (Adenoma Cohort) 4. Ability to provide informed consent
Exclusion
sessile serrated lesion or hyperplastic polyp on histologic diagnosis (Serrated Cohort) or
conventional adenoma on histologic diagnosis (Adenoma Cohort) 3. Patients with Ulcerative Colitis or Crohn's disease 4. Polyps with features suggestive of submucosal invasion 5. Polyps that are not able to be removed endoscopically due to location (e.g. extending into appendiceal orifice or diverticulum) 6. Patients with a known or suspected diagnosis of any of the following polyposis syndromes with known genetic mutations:
Familial Adenomatous Polyposis Syndrome
MUTYH associated Polyposis Syndrome
Juvenile Polyposis Syndrome
Cowden's Syndrome
Peutz-Jeghers Syndrome 7. Subjects whose colonoscopy procedure is not able to be completed due to bowel prep precluding polyp identification.
What this trial measures
- Efficacy of Resection (Central Post-Resection Biopsies)1 day
Efficacy of resection will be assessed by biopsies in four or six quadrants of the perimeter of the defect post-resection and two biopsies from the center of the defect post-resection. Comparison of the biopsy pathology results for polyps removed by Cold EMR vs CSPR.
- Efficacy of Resection (Peripheral Post-Resection Biopsies)1 day
Efficacy of resection will be assessed by biopsies in four or six quadrants of the perimeter of the defect post-resection and two biopsies from the center of the defect post-resection. Comparison of the biopsy pathology results for polyps removed by Cold EMR vs CSPR.