NCT06464315
Functional Substrate-Only Guided VT Ablation
Enrolling by Invitation
NAAges 18–90InterventionalTreatmentVA Office of Research and DevelopmentGovernment-funded
~36 participants
Updated 2026-03-25 on ClinicalTrials.gov
What's tested:Functional Substrate-Only Mapping without VT InductionStandard-of-Care Mapping/Imaging
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time to composite endpoint (VT recurrence, death, or acute hemodynamic decompensation)
Measured over 6 months
Conditions
Where it's being run
1 sites across 1 statesCalifornia1
Study leadership
- Gordon Ho, MD · PRINCIPAL_INVESTIGATOR · VA San Diego Healthcare System, San Diego, CA
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Men and women \>18 years of age referred for clinically indicated VT ablation and experience monomorphic or polymorphic scar-based VT documented by telemetry, ICD interrogation, ECG or event monitoring.
Scar-based VT is defined as VT in patients with structural heart disease (assessed with either abnormal nuclear perfusion imaging (\>5% defect), late gadolinium uptake on cardiac MRI, wall thinning \<10mm or calcified myocardium on cardiac CT, akinesis or hypokinesis on echocardiogram, presence of Q waves on ECG, history of myocardial infarct).
Patients undergoing epicardial VT ablation and who undergo prophylactic percutaneous hemodynamic support devices will also be included.
Exclusion
Patients without structural heart disease will be excluded from the pri-mary analysis, but enrolled in a prospective registry
Patients who are pregnant
Presence of intracardiac thrombus
active acute coronary ischemia with unrevascularized coronary artery disease (CAD \>70% stenosis)
Active bacteremia
Inaccessible ventricles due to dual mechanical valves
Inability to tolerate and inability to tolerate anticoagulation during ablation and for at least 1 month after ablation
What this trial measures
- Time to composite endpoint (VT recurrence, death, or acute hemodynamic decompensation)6 months
Ventricular arrhythmia recurrence is defined by an episode of sustained VT lasting 30 seconds or appropriate implantable cardioverter-defibrillator therapy including anti-tachycardia pacing or shock. Acute hemodynamic decompensation is defined by escalation of at least 1 new high dose inotrope/pressor occurring after anesthesia induction with persistent requirement during stable rhythm, \>20% drop in cardiac index, unplanned insertion of percutaneous hemodynamic support device.