Study of Cemiplimab Plus Chemotherapy for Operable Non-Small Cell Lung Cancer

This study is for adults with early-stage non-small cell lung cancer (NSCLC) that can be removed by surgery. Researchers want to see if adding a third drug, REGN7075, to cemiplimab (an immunotherapy) and platinum-based chemotherapy works better than cemiplimab plus chemotherapy alone. The study will also look at side effects, how the treatments affect surgery, and how much of the drugs are in your blood. You may be able to join if you have Stage II-IIIB NSCLC, measurable disease, and can provide a tumor sample. The main goal is to see how many participants have a major pathologic response (meaning most of the cancer cells are gone) after treatment, measured up to 12 weeks.

Study design
This is an interventional study planning to enroll 120 adult participants. The specific phase of the study is not mentioned.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, major pathologic response, is measured up to 12 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06465329

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Active, Not Recruiting
PHASE2Ages 18+InterventionalTreatment
Regeneron Pharmaceuticals
~120 participants
Updated 2026-08-24 on ClinicalTrials.gov
What's tested:CemiplimabPlatinum-based chemotherapyREGN7075

At a glance

Recruiting sites
0 of 47 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Major pathologic response (MPR) rate as determined by central blinded independent pathology review (BIPR)
Measured over Up to 12 weeks
Non-Small Cell Lung Cancer
47 sites across 31 states
Spain8
France4
Michigan2
Oregon2
Tennessee2
Minas Gerais2
Rio Grande do Sul2
São Paulo2
  • Clinical Trial Management · STUDY_DIRECTOR · Regeneron Pharmaceuticals

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Major pathologic response (MPR) rate as determined by central blinded independent pathology review (BIPR)Up to 12 weeks