This study, called Lunar OI, is looking at how men and women respond differently to changes in gravity, similar to what astronauts experience during lunar missions. Researchers want to see if there are differences in how well men and women tolerate standing up (orthostatic intolerance) and how their heart and blood vessels react. You might receive a potassium supplement to prevent low potassium levels, and furosemide (Lasix), a medication given through an IV to help you urinate and reduce your blood volume. You'll also wear a custom-designed compression garment. The study aims to see how these interventions affect your ability to tolerate tilting and the stress on your cardiovascular system. We'll measure your blood plasma volume, how long you can tolerate tilting, and your heart rate. This study is for healthy individuals aged 25 to 55 years old. The current recruitment status is unclear.

Study design

This is an interventional study planning to enroll 38 healthy participants. It has a two-phased design, with the first phase focusing on differences between males and females.

What's involved

You will have measurements taken for a custom compression garment and undergo a tilt familiarization process. During this, you'll lie still while instruments measure your blood pressure and heart rate, and then you'll be tilted to an 80-degree head-up position.

Compensation

Not stated in the trial record.

Follow-up

Your plasma volume will be measured at 7-8 hours, and your tilt tolerance time and heart rate will be measured at 0-20 minutes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.