Aspirin Dosing for Hypertensive Disorders of Pregnancy

This study is looking at whether 162 mg of Aspirin works better than 81 mg of Aspirin to prevent high blood pressure problems during pregnancy, like preeclampsia and gestational hypertension. These conditions can cause serious health issues for both mother and baby. You might be able to join if you are a woman between 14 and 35 years old, are less than 17 weeks pregnant, and have a higher risk for these conditions, such as having had preeclampsia before or having chronic high blood pressure. The main goal is to see if one dose of Aspirin is more effective at preventing these conditions from 20 weeks of pregnancy until after delivery. The current status of this large study, which plans to enroll over 10,000 participants, is unclear.

Study design
This is an interventional study comparing two doses of Aspirin (81 mg vs. 162 mg) in over 10,000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed from 20 weeks gestation until hospital discharge after delivery, up to 22 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06468202

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

Recruiting
PHASE4Ages 14–35InterventionalPrevention
Ohio State University
~10,742 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:Aspirin 81 mgAspirin 162 mg

At a glance

Recruiting sites
16 of 16 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hypertensive Disorder of Pregnancy (HDP)
Measured over From >20 weeks gestation until hospital discharge following delivery, up to 22 weeks
Hypertensive Disorders of Pregnancy
Preeclampsia
Gestational Hypertension
16 sites across 14 states
California2
Virginia2
Alabama1
Illinois1
Mississippi1
New Mexico1
New York1
North Carolina1
  • Maged Costantine, MD, MBA · PRINCIPAL_INVESTIGATOR · Ohio State University
  • Denise Sholtens, PhD · PRINCIPAL_INVESTIGATOR · Northwestern University Data Analysis and Coordinating Center

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  • Hypertensive Disorder of Pregnancy (HDP)From >20 weeks gestation until hospital discharge following delivery, up to 22 weeks

    HDP defined as preeclampsia or antepartum gHTN based on ACOG criteria