C-peptide for Hypoglycemia in Type 1 Diabetes

This study is looking at how a natural protein called C-peptide might help people with type 1 diabetes when their blood sugar gets too low (hypoglycemia). When blood sugar drops, the body usually releases a hormone called glucagon to raise it. However, in type 1 diabetes, this response can be weak. Researchers want to see if giving C-peptide during low blood sugar episodes can increase glucagon and help the body produce more sugar. You might be able to join if you are 18-40 years old, have a BMI (Body Mass Index) under 30, and do not smoke, are not pregnant, and don't have certain other health conditions like heart disease. The main goal is to measure glucagon levels during the procedure. The current status of the study is unclear, and it plans to enroll 38 participants.

Study design
This interventional study will involve healthy volunteers and people with type 1 diabetes. Participants will receive either C-peptide or a saline (saltwater) infusion during insulin-induced low blood sugar.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Glucagon levels will be measured during the procedure, up to 2.5 hours.

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NCT06470295

Effect of C-peptide on Hypoglycemic Counterregulation

Recruiting
EARLY_PHASE1Ages 18–40InterventionalBasic science
University of Cincinnati
~38 participants
Updated 2026-02-17 on ClinicalTrials.gov
What's tested:SalineC-peptide

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Glucagon
Measured over During procedure, up to 2.5 hours
Hypoglycemia
Type 1 Diabetes
1 sites across 1 states
Ohio1
  • Jason Winnick, PhD · PRINCIPAL_INVESTIGATOR · University of Cincinnati

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Eligibility criteria

Inclusion

BMI less than 30 kg/m2

Exclusion

pregnant or lactating women cigarette smoking presence of HIV or hepatitis presence of cardiovascular disease presence of microvascular disease
  • GlucagonDuring procedure, up to 2.5 hours

    from plasma