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Mapping Brain Electrical Properties in Malignant Glioma

This study aims to improve how we monitor brain activity and diagnose conditions like malignant glioma (a type of brain cancer). Researchers are using advanced MRI (magnetic resonance imaging) techniques, specifically diffusion MRI, to create detailed maps of the brain's electrical properties. They want to see if these maps can accurately show how healthy and diseased brain tissue is functioning. The study will compare these new MRI methods with existing brain imaging techniques and information from biopsies (tissue samples) and patient outcomes. You may be able to join if you are a healthy volunteer or if you have suspected or known glioma and are already part of another study (IRB 16-002424). The goal is to identify specific diffusion MRI measurements that can reveal important electrical information about the brain.

Study design
This is an observational study planning to enroll 120 participants. It is not testing a new drug or treatment.
What's involved
Participants will complete a survey and undergo an MRI scan during the study.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, identifying diffusion MRI metrics, is measured at Baseline. No further follow-up is specified.

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NCT06470711

Mapping of Electrical Properties in the Brain

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~120 participants
Updated 2026-02-03 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identify diffusion MRI metrics [using conductivity tensor imaging (CTI)] that inform of regional electrical properties in the brain
Measured over Baseline

Conditions

Malignant Glioma

Explore related trials

Malignant Glioma

Where it's being run

1 sites across 1 states
Arizona1

Study leadership

  • Leland S. Hu, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Clinical Trials Referral Office
[email protected]
855-776-0015
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Aim 1: normal healthy volunteers
Aim 2, 3, 4: participants included in IRB 16-002424, including those that have undergone surgical biopsy/resection for suspected or known glioma

Exclusion

Healthy volunteer unable to have an MRI

What this trial measures

  • Identify diffusion MRI metrics [using conductivity tensor imaging (CTI)] that inform of regional electrical properties in the brainBaseline

    At least 4 normal white matter regions of the brain will be analyzed. Fractional anisotropy (FA) and optimized diagnostic imaging (ODI) values will be compared to determine alignment within normal healthy white matter tracts (e.g. cortical spinal tract, corpus callosum).