Investigation of Two Photon Fluorescence Microscopy for Basal Cell Carcinoma

This study is looking at a new way to check surgical margins (the edges of removed tissue) for basal cell carcinoma (a common type of skin cancer). Researchers are using a device called two photon fluorescence microscopy (TPFM) to image the removed tissue right after surgery. The goal is to see how well TPFM can identify any remaining cancer cells compared to the standard method used in the lab. You might be able to join if you are having basal cell carcinoma removed without Mohs surgery at the study location and can understand the consent form. The study will be considered successful if the TPFM measurements of clear margins closely match the results from the standard lab tests. The current recruitment status is unclear.

Study design
This is an interventional study that plans to enroll 52 participants. It will compare a new imaging technique to standard lab tests.
What's involved
Your excised tissue will be imaged with two photon fluorescence microscopy before it goes to the lab for standard processing. All patients will receive standard care confirmation after the experimental imaging.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured upon receipt of postoperative pathology slides, typically 2-4 weeks post surgery.

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NCT06473103

Investigation of Standard Excision Surgical Margins Using Two Photon Fluorescence Microscopy

Recruiting
NAAll AgesInterventionalDiagnostic
University of Rochester
~52 participants
Updated 2025-03-17 on ClinicalTrials.gov
What's tested:Two photon fluorescence microscopy imaging

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Quantitative agreement between clear margin distance on TPFM and conventional paraffin embedded histology
Measured over Upon receipt of postoperative pathology slides, typically 2-4 weeks post surgery
Basal Cell Carcinoma
1 sites across 1 states
New York1
  • Michael Giacomelli · PRINCIPAL_INVESTIGATOR · University of Rochester

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Eligibility criteria

Inclusion

Undergoing treatment for basal cell carcinoma without Mohs surgery at the performance site
Able to read and understand consent form

Exclusion

None
  • Quantitative agreement between clear margin distance on TPFM and conventional paraffin embedded histologyUpon receipt of postoperative pathology slides, typically 2-4 weeks post surgery

    The distance from the furthest extent of the tumor to the nearest surgical margin will be measured on both TPFM and conventional paraffin histology and the numerical difference calculated.