The Avenues Study: Quitting Smoking and Vaping

This study, called "The Avenues Study," is looking for the best ways to help people who use both cigarettes and electronic cigarettes (vapes) quit smoking. It will test different approaches, including two medications: varenicline (a pill) and nicotine patches. It will also compare two types of counseling: one that helps you quit both smoking and vaping, and another that focuses on quitting smoking while using vaping to help reduce harm. You can join if you are 21 or older, speak English, smoke at least 5 cigarettes daily, vape weekly, and are willing to set a quit date for smoking within 30 days. The main goal is to see how many people successfully quit smoking for at least 7 days, confirmed by a test, up to 52 weeks after starting the study. The study plans to enroll 500 participants, but its current status is unclear.

Study design
This is a randomized study that will enroll 500 participants. It will compare different combinations of medications and counseling approaches.
What's involved
You will be on the study for 12 months. You will take either varenicline or nicotine patches, and participate in either one or four counseling sessions.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be checked for up to 52 weeks after you start the study to see if you have quit smoking.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06474299

The Avenues Study: Dual Use Cessation

Recruiting
PHASE4Ages 21+InterventionalTreatment
University of Wisconsin, Madison
~500 participants
Updated 2026-04-13 on ClinicalTrials.gov
What's tested:VareniclineNicotine patchDual Focused Cessation CounselingSmoking Focused Cessation CounselingCounseling Intensity: 1 SessionCounseling Intensity: 4 Sessions

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
52-week biochemically confirmed 7-day point-prevalence abstinence from cigarettes
Measured over up to 52 weeks
Smoking Cessation
Electronic Cigarette Use
1 sites across 1 states
Wisconsin1
  • Megan E Piper, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Able to read and communicate in English
Willing to set a quit date to quit smoking cigarettes in the next 30 days
Willing and medically able to use varenicline and nicotine patches
Smoking ≥ 5 cigarettes per day for the past 6 months
Vaping weekly for at least 6 months
Willing to stop using nicotine replacement or varenicline
Willing to stop using bupropion (i.e., Wellbutrin, Zyban) if they are currently using it only for smoking cessation
Saliva cotinine \>20 ng/ml
US resident
Own a Smartphone to use and download an app to record data
have a working email so that they can receive links for video visits

Exclusion

Currently in treatment for psychosis or bipolar disorder
If they are currently taking bupropion for non-smoking cessation reasons (e.g., Wellbutrin for depression)
Currently pregnant or breastfeeding. If a participant becomes pregnant while in the study, they will be allowed to continue in the study but will no longer receive study medications. They will also be asked to return any unused study medications.
  • 52-week biochemically confirmed 7-day point-prevalence abstinence from cigarettesup to 52 weeks

    52-week biochemically confirmed (anabasine\<2 ng/ml) 7-day point-prevalence abstinence from cigarettes