Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat

This study is looking for healthy, physically active adults aged 18 to 39 to understand how different work and rest cycles affect your body's temperature and strength during exercise in the heat. You would walk on a treadmill with a weighted backpack, following one of four work/rest cycles: 30 minutes work/30 minutes rest, 30 minutes work/20 minutes rest, 40 minutes work/30 minutes rest, or 20 minutes work/12 minutes rest. The goal is to find the best balance between completing tasks faster and preventing heat stress and muscle fatigue. Researchers will measure your core temperature and leg strength to see which cycle is most effective. The study plans to enroll 24 participants, but its current recruitment status is unclear.

Study design: This is an interventional study involving 24 participants. It compares four different work/rest cycles.
What's involved: You would walk on a treadmill with a weighted backpack, following specific work/rest cycles. Your core temperature and leg strength will be measured at 180 minutes of work.
Compensation: Not stated in the trial record.
Follow-up: Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat

Recruiting

NAAges 18–39InterventionalPrevention

State University of New York at Buffalo

~24 participants

Updated 2026-01-26 on ClinicalTrials.gov

What's tested:30/30 work/rest cycle30/20 work/rest cycle40/30 work/rest cycle20/12 work/rest cycle

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Core temperature

Measured over 180 minutes of work

+1 more outcome measured

Conditions

Hyperthermia

Fatigue; Heat

Where it's being run

1 sites across 1 states

New York1

Study leadership

Riana R Pryor, PhD · PRINCIPAL_INVESTIGATOR · University at Buffalo

Who to contact

Riana R Pryor, PhD

[email protected]

7168295456

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy individuals

Physically active

Exclusion

History of cardiovascular, metabolic (such as clinical thyroid disease), respiratory, neural, or renal disease

Hypertensive (systolic blood pressure \> 139 mmHg, diastolic blood pressure \> 89 mmHg) or tachycardic (heart rate \> 100 bpm) during the screening visit

Taking medications or supplements known to effect physiologic responses to exercise or thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)

Tobacco or nicotine use currently or in the past six months

Musculoskeletal injury expected to impact exercise in the protocol

A positive pregnancy test at any point in the study

Study physician discretion based on any other medical condition or medication

Inability to understand or follow instructions or the protocol

Gastrointestinal disease or previous surgery prohibiting core temperature capsule use. Participants with a contraindication can opt to insert the pill rectally as a suppository.

What this trial measures

Core temperature180 minutes of work
Maximum gastrointestinal temperature reached during the work protocol
Isometric mid-thigh pull strength180 minutes of work
Maximum voluntary contraction strength assessed using a force plate

Trialytics