Chardonnay Marc for Gut and Cardiometabolic Health

This study is looking at how eating Chardonnay Marc, which are the skins and seeds of Chardonnay grapes, might affect your gut and heart health. Researchers want to see if this food product, rich in natural plant compounds called flavanols, can help improve your health. You might be able to join if you are a postmenopausal woman between 45 and 70 years old, have a BMI between 25 and 49.9 kg/m2, and have fasting triglycerides (a type of fat in the blood) above 120 mg/dL. The main goal is to see how Chardonnay Marc affects microvascular function (how well your small blood vessels work) after 12 weeks. The current status of this study is unclear, and it plans to enroll 5 participants.

Study design
This is an interventional study, meaning participants will receive a specific intervention (Chardonnay Marc). It is a small pilot study planning to enroll 5 women.
What's involved
You would have 3 study visits over 12 weeks. At each visit, about 3.5 tablespoons of blood will be collected. You will eat Chardonnay Marc daily for 12 weeks, starting with 1.5g for the first 6 weeks and increasing to 4.5g for the remaining 6 weeks, and log your intake.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 weeks, with microvascular function measured at the end of this period.

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NCT06476795

The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health

Recruiting
NAAges 45–70Interventional
University of California, Davis
~5 participants
Updated 2026-08-07 on ClinicalTrials.gov
What's tested:Chardonnay Marc

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Microvascular function
Measured over 12 weeks
Cardiovascular Diseases
Adiposity
Cardiometabolic Syndrome
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Postmenopausal female, with a cessation of menses for at least 2 years
45-70 years of age
BMI 25- 49.9 kg/m2
Fasting triglycerides \> 120 mg/dL
Subject is willing and able to comply with the study protocols and procedures.

Exclusion

Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
Prescription medications and supplements, except for a 6 month stable dose of thyroid medications
Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
Fruit consumption ≥ 3 cups/day
Vegetable consumption ≥ 4 cups/day
Coffee/tea ≥ 3 cups/day
Dark chocolate ≥ 3 oz/day
Self-reported restriction of physical activity due to a chronic health condition
Self-reported chronic/routine high intensity exercise
Blood pressure ≥ 140/90 mm Hg
Self-reported renal or liver disease
Self-reported heart disease, which includes cardiovascular events and stroke, diabetes
Peripheral artery disease Raynaud's syndrome or disease
Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT
Self-reported cancer within past 5 years
Self-reported gastrointestinal disorders, apart from appendix removal
Unwillingness to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements six weeks prior to study enrollment.
Indications of substance or alcohol abuse within the last 3 years
All forms of smoking (e.g. vaping, cigarette, cannabis)
Current enrollee in a clinical research study.
  • Microvascular function12 weeks

    Microvascular function measured by peripheral arterial tonometry