Dronabinol Treatment for Obstructive Sleep Apnea

This study is testing Dronabinol, an oral medication, to see if it can help treat obstructive sleep apnea (OSA). OSA is a serious breathing problem during sleep. All participants will take Dronabinol for two weeks. Researchers will conduct sleep studies before and after treatment to measure how much the OSA has improved. The main goal is to see if Dronabinol reduces the number of times breathing stops or becomes very shallow during sleep (Apnea Hypopnea Index or AHI). This study is looking for adults aged 18 to 65 who have moderate to severe OSA (AHI between 15 and 50). You cannot participate if you use a CPAP machine for more than 4 hours a day for 30% of days in the last three months. The current status of this study is unclear, and it plans to enroll up to 120 participants.

Study design
This is an open-label study, meaning everyone knows they are receiving Dronabinol. It plans to enroll up to 120 participants.
What's involved
You would take oral Dronabinol for two weeks. Sleep studies will be conducted before and after this treatment period.
Compensation
Not stated in the trial record.
Follow-up
Your AHI will be measured at 2 weeks after starting treatment.

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NCT06477952

DRonabinol Treatment of OSA

Recruiting
PHASE1Up to 65InterventionalTreatment
VA Office of Research and Development
~120 participants
Updated 2026-08-11 on ClinicalTrials.gov
What's tested:Dronabinol

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Apnea hypopnea index (AHI)
Measured over 2 weeks
Obstructive Sleep Apnea
1 sites across 1 states
Illinois1
  • Bharati Prasad, MD · PRINCIPAL_INVESTIGATOR · Jesse Brown VA Medical Center, Chicago, IL

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  • Apnea hypopnea index (AHI)2 weeks

    The change in AHI after two weeks of Dronabinol treatment will be determined from before and after treatment polysomnograms.