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Exercise and Beetroot Juice for Post-Menopausal Women

This study is looking at how different exercise intensities and a drink called Nitrate-Rich Beetroot Juice affect heart health and fitness in women after menopause. Menopause can increase the risk of heart disease, and researchers want to see if combining specific exercise with this juice can help. You might receive Nitrate-Rich Beetroot Juice or a placebo (Nitrate-Depleted Placebo Beetroot Juice), along with either High Intensity Exercise or Moderate Intensity Exercise. The main goals are to measure your blood vessel health (Vascular Endothelial Function) and how fit your heart and lungs are (Cardiorespiratory Fitness) at the beginning and after one month of exercise training. We are looking for women aged 45 to 75 who are post-menopausal and don't exercise regularly.

Study design
This is an interventional study planning to enroll 40 participants. It will compare different exercise intensities with and without beetroot juice supplementation.
What's involved
You would participate in exercise training for one month, with measurements taken at the start and end of this period. You would also consume beetroot juice twice a day.
Compensation
Not stated in the trial record.
Follow-up
Your vascular function and cardiorespiratory fitness will be measured after 1-month of exercise training.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06480695

Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females

Recruiting
NAAges 45–75InterventionalSupportive care
University of Virginia
~40 participants
Updated 2026-07-17 on ClinicalTrials.gov
What's tested:Nitrate-Rich Beetroot JuiceHigh Intensity ExerciseModerate Intensity ExerciseNitrate-Depleted Placebo Beetroot Juice

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Vascular Endothelial Function (Flow-Mediated Dilation [FMD])
Measured over Baseline and after 1-month of exercise training
+1 more outcome measured

Conditions

Menopause

Explore related trials

Menopause present

Where it's being run

1 sites across 1 states
Virginia1

Study leadership

  • Jason Allen, PhD · PRINCIPAL_INVESTIGATOR · UVA

Who to contact

Macy Stahl
[email protected]
434-924-1655
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Post-menopausal female (greater than age 45 but less than age 75)
Sedentary (does not exercise regularly or less than 2 bouts of exercise per week)
No major changes in medication in the last 3 months

Exclusion

Smokers within last 5 years
Weight unstable (loss/gain of more than 3kg in the past 3 months)
Any medical condition that prevents the subject from exercising safely
Hormone replacement therapy (current or within last 3 months)
Diabetes
Currently or recently on vasoactive medications (i.e., calcium channel blockers, statins, ACE or renin inhibitors, ARBs, nitrates, alpha- or beta-blockers, diuretics, proton pump inhibitors, etc.)
Oral antibiotic use within previous four weeks
Oral disease or poor oral health as determined by the Oral Health Questionnaire
Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use

What this trial measures

  • Vascular Endothelial Function (Flow-Mediated Dilation [FMD])Baseline and after 1-month of exercise training

    Participants will be placed in a supine position with their left forearm slightly extended and supinated with legs straight. The arteries will be imaged using a high-resolution 7.5MHz linear array transducer at rest, during 5 minutes of forearm occlusion via cuff inflation, and continuously for 3 minutes post-occlusion; an EKG trigger will be used to capture images during end-diastole of the cardiac cycle.

  • Cardiorespiratory FitnessBaseline and after 1-month of exercise training

    Peak aerobic capacity (VO2peak) will be assessed using a symptom-limited graded exercise test on a treadmill. An IV will be placed and lactate measured during rest and after the completion of every 3-minute stage to determine lactate threshold at VO2peak.