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Exercise and Blood Changes in Restless Legs Syndrome

This study aims to understand how exercise affects the blood in people with restless legs syndrome (RLS). Researchers want to see if a 12-Week RLS Exercise Program changes proteins in the blood, both after a single exercise session and over a longer period. You might be able to join if you are 18 or older, have moderate-to-severe RLS that is currently untreated, and are not regularly active. The study will compare people who exercise to those who don't, to see if any changes in blood proteins are specifically due to exercise. This could help us better understand what causes RLS.

Study design
This is an interventional study with 30 participants. You will be randomly assigned (like a coin flip) to either an exercise group or a no-exercise group.
What's involved
You will complete an exercise test and provide blood samples at the beginning and again after 12 weeks. If in the exercise group, you will follow a 12-week exercise program.
Compensation
Not stated in the trial record.
Follow-up
Blood samples and protein profiles will be measured at the 12-week follow-up appointment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06481176

Blood Changes After Exercise in Restless Legs Syndrome

Recruiting
NAAges 18+InterventionalTreatment
Stanford University
~30 participants
Updated 2024-11-27 on ClinicalTrials.gov
What's tested:12-Week RLS Exercise Program

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Protein Expression Profile
Measured over Twice at Baseline Appointment
+1 more outcome measured

Conditions

Restless Legs Syndrome

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Restless Leg Syndrome

NCT06481176

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Stanford University

    Stanford, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Emmanuel Mignot, MD, PhD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

Katie Cederberg, PhD
[email protected]
(650) 725-6517
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

age 18 years or older;
diagnosis of RLS;
presence of moderate-to-severe RLS (IRLS score\>15);
currently untreated RLS;
being non-active defined as not engaging in regular activity (30 minutes accumulated per day) on more than 2 days of the week during the previous six months;
ability to walk without assistance (does not use a cane/walker/wheelchair for mobility;
willing to complete outcome measures and complete the exercise program

Exclusion

present with a condition that can mimic RLS or cause secondary RLS (e.g., iron deficiency anemia, radiculopathy, peripheral edema, peripheral neuropathy, diabetes);
are at moderate or high risk for undertaking strenuous or maximal exercise

What this trial measures

  • Protein Expression ProfileTwice at Baseline Appointment

    Participants will provide blood samples that will be used to measure proteins in the blood with an aptamer-based multiplexed platform of 11,000+ proteins. Two samples will be collected at the baseline testing session (before the 12-week study period); one right before and one right after the cardiorespiratory fitness test.

  • Protein Expression ProfileTwice at the 12-week Follow-Up

    Participants will provide blood samples that will be used to measure proteins in the blood with an aptamer-based multiplexed platform of 11,000+ proteins. Two samples will be collected at the follow-up testing session (after the 12-week study period); one right before and one right after the cardiorespiratory fitness test.