Take the Reins: Nutrient Timing for Cancer-related Fatigue

This study, called "Take the Reins," is looking at how eating at specific times might help with cancer-related fatigue. Fatigue is a common and often long-lasting problem for people with cancer that isn't helped by rest. Researchers believe that eating patterns might affect your body's internal clock (circadian rhythm), which could play a role in fatigue. This study will test two approaches: time-restricted eating, where you eat all your food within a 10-hour window each day, and nutrition counseling, where you'll discuss your eating habits with a nutritionist. The main goal is to see if these interventions can reduce fatigue. You may be able to join if you are an adult (18+) with a blood cancer (like leukemia, lymphoma, or multiple myeloma) and are at least two months past most cancer treatments. The study aims to enroll 96 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive specific interventions. It plans to enroll 96 participants.
What's involved
Participants will be asked to eat all their food within a self-selected 10-hour window daily and will meet with a nutritionist. Fatigue will be measured at the start, at 6 weeks, and at 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Fatigue will be measured up to 12 weeks after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06482515

Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue

Recruiting
PHASE2Ages 18+InterventionalSupportive care
University of Maryland, Baltimore
~96 participants
Updated 2026-06-05 on ClinicalTrials.gov
What's tested:Time-restricted eatingNutrition counseling

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Fatigue
Measured over baseline, 6 weeks, 12 weeks
Neoplasms
Blood Cancer
Fatigue
Diet Habit
Survivorship
Fasting, Intermittent
1 sites across 1 states
Maryland1

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Eligibility criteria

Inclusion

Have a diagnosis of a hematologic neoplasm (e.g., leukemia, lymphoma, multiple myeloma);
Be at least 2 months post-treatment with chemotherapy, radiation, targeted therapy, chimeric antigen receptor (CAR)-T cell therapy, stem cell transplant, or another therapy (maintenance therapies are okay; steady unchanged treatment for relapsed disease for \>2 months and expected to stay on it until progression is okay);
Have a baseline level of fatigue, as determined by at least one of the following:
Be able to speak and/or read and write in English or Spanish;
Be at least 18 years old; and
Be able to provide informed consent.

Exclusion

Be underweight, as defined as a body mass index \<18.5 kg/m2;
Already eat all their food within a window that is 10 h or shorter most (6/7) days of the week;
Be employed in a job where they regularly work away from the home at night (e.g., night shift);
Have surgery planned during the study duration;
Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., type 1 diabetes, risk for hypoglycemia, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder);
Be taking insulin; or
Be on enteral or parenteral nutrition.
  • Fatiguebaseline, 6 weeks, 12 weeks

    Multidimensional Fatigue Symptom Inventory-Short Form; the total MFSI-SF score ranges from -24 to 96 with a higher score indicating higher levels of fatigue