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Laser-Induced Rejuvenation for Skin Cancer Protection

This study is looking into how Fractionated Laser Resurfacing (FLR), a rejuvenating laser treatment, helps protect skin from cancer. Researchers want to understand where new cells called fibroblasts come from after this laser treatment. These fibroblasts are important because they help skin respond to sunlight (ultraviolet B or UVB) in a more youthful way. You might be able to join if you are an adult, 18 or older, and are already planning to have abdominoplasty surgery where a minimum of 50 x 20cm of skin will be removed. The study aims to enroll 12 participants and is currently unclear on its recruitment status. This research could help us better understand how laser treatments can protect against skin cancer.

Study design
This is an interventional study planning to enroll 12 adult participants. It is not specified if it is randomized or blinded.
What's involved
Participants will have skin samples taken at two time points: two weeks and one week before their planned abdominoplasty surgery.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06489301

Mechanisms for Laser-Induced Rejuvenation

Recruiting
NAAges 18+InterventionalPrevention
Wright State University
~12 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Fractionated Laser Resurfacing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To test if the new fibroblasts that develop in response to fractionated laser resurfacing (FLR) wounding are derived from blood-derived monocytes.
Measured over 2 weeks prior to skin removal and 1 week prior to skin removal
+1 more outcome measured

Conditions

Skin Cancer

Explore related trials

Malignant Skin Neoplasm

NCT06489301

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Pharmacology Translational Unit

    Fairborn, Ohiostudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jeffrey Travers, MD, PhD · PRINCIPAL_INVESTIGATOR · Wright State University

Who to contact

Manager, Clinical Research Operations
[email protected]
937-245-7500
Email the study team

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Eligibility criteria

Inclusion

Adult males and females 18 and older
Able to comprehend procedures and risks
Planning to undergo abdominoplasty surgery
Minimum amount of skin to be removed is 50 x 20cm

Exclusion

Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded.
Pregnant or nursing
History of pathologically abnormal wound healing such as keloidal scars
Existing tattoos on the abdomen that are so extensive that they could interfere with the study

What this trial measures

  • To test if the new fibroblasts that develop in response to fractionated laser resurfacing (FLR) wounding are derived from blood-derived monocytes.2 weeks prior to skin removal and 1 week prior to skin removal

    Identify cells in the skin that have been wounded by FLR at 2 weeks and 1 week previously, for cells that co-express markers for both fibroblasts and monocytes by using single cell RNA-sequencing

  • To test if possible cells transitioning from monocytes to fibroblasts are found in the top part of the dermis (papillary dermis).2 weeks prior to skin removal and 1 week prior to skin removal

    Using tissue RNA-seq, PI will define if co-expressing cells are in the papillary dermis.