Action Regulation Behavioral Study for Parkinson's Disease

This study is looking at how people with Parkinson's disease (PD) control their movements and make decisions. Researchers are using a special joystick task called the Action Regulation Movement Task to understand how PD affects your ability to start, stop, and change movements. You might be able to join if you are between 18 and 80 years old, have been diagnosed with Parkinson's disease by a neurologist, and your symptoms improve by at least 30% when you take levodopa. The study will measure your performance on tasks like the Stop-Signal Task and Switch Task to see how well you can control your actions.

Study design: This is an interventional study planning to enroll 50 participants. The phase of the study is not specified.
What's involved: You would complete behavioral experiments for up to 3 hours, which involve using a joystick to trace movements on a computer screen.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoints, Stop-Signal Task and Switch Task, are measured at Baseline.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Action Regulation Behavioral

Recruiting

NAAges 18–80InterventionalBasic science

University of Texas Southwestern Medical Center

~50 participants

Updated 2025-12-12 on ClinicalTrials.gov

What's tested:Action Regulation Movement Task

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Stop-Signal Task

Measured over Baseline

+1 more outcome measured

Conditions

Parkinson Disease

NCT06489483

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

University of Texas Southwestern Medical Center
Dallas, Texasstudy coordinator listed
Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Nader Pouratian, MD, Phd

[email protected]

(214) 645-5465

Email the study team

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Eligibility criteria

Inclusion

Diagnosis of Parkinson's Disease by a movement disorder neurologist

Levodopa responsive with clearly defined "on" periods, with at least 30% improvement in UPDRS III scores on vs off

Willingness and ability to complete the behavioral experiments for up 3.5 hours

No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators

No history any diagnosed neurological disease(s), including movement disorders or cognitive decline

No vision or hearing problems that impair ability to participate with the proposed tasks as assessed by the study investigators

Exclusion

Patients with history of secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's Disease

Patients with a disease or condition that prevents understanding or communication of informed consent, study demands, and testing protocol including cognitive decline, diagnosed forms of dementia, significant memory impairment (MoCA\<23), or hearing loss that prevents adequate communication with researcher

What this trial measures

Stop-Signal TaskBaseline
Each patient will complete a joystick-based stop-signal task which assesses reaction time, stop reaction time, accuracy, and joystick traces.
Switch TaskBaseline
Each patient will complete a joystick-based switch task which assess reaction time, switch reaction time, accuracy, and joystick traces.

Trialytics