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NCT06489561

Neural Computations of Goal-directed Decision-making

Enrolling by Invitation
NAAges 18–65InterventionalBasic science
Cedars-Sinai Medical Center
~50 participants
Updated 2026-07-23 on ClinicalTrials.gov
What's tested:Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Decision Making (Firing Rates)
Measured over 5 years
+2 more outcomes measured

Conditions

Epilepsy Intractable

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Intractable Epilepsy

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Ueli Rutishauser, PhD · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center
  • Adam Mamelak, MD · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center
  • John O'Doherty, PhD · PRINCIPAL_INVESTIGATOR · California Institute of Technology

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Intractable epilepsy, undergoing invasive monitoring
Age ≥13
Full Scale Intelligence Quotient \> 70
Ability to comprehend and perform simple behavioral tasks by pressing buttons on laptop computer in response to questions

Exclusion

Determination by clinicians and investigators that a patient is unable to complete the behavioral tasks required for the protocol due to either cognitive limits, psychological limits, or pain

What this trial measures

  • Decision Making (Firing Rates)5 years

    Neuronal firing rates of cells (measured in spike rates per second) in the frontal lobes during a decision-making process.

  • Decision Making (Power)5 years

    Power of local field potential bandwidths (measured in amplitude across frequency of the bandwidths) in the frontal lobes during a decision-making process.

  • Decision Making (Timing)5 years

    Timing of neuronal discharges (measured in spike rates per second) across the frontal lobes during a decision-making process.