Developing a New Way to Screen Alcohol Use Disorder Medications

This study aims to create new ways to test medications for Alcohol Use Disorder (AUD). Researchers are developing two models to see how alcohol cues (things that make you want to drink) and alcohol availability affect how long someone can resist drinking and how much they drink. Model 1 looks at these factors, while Model 2 adds a small "priming" dose of alcohol. The study wants to enroll 90 participants aged 21 to 65 who meet criteria for AUD. Success for this study means understanding how these models can measure alcohol consumption after 120 minutes. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 90 participants. It is designed to develop two models for screening AUD medications.
What's involved
You would have an intake session, a physical exam, and two laboratory sessions. During lab sessions, you can choose to delay drinking for money or drink alcohol for up to two hours.
Compensation
You can receive monetary reinforcement for delaying drinking and monetary compensation for alcohol not consumed.
Follow-up
Alcohol consumption is measured at 120 minutes during the self-administration sessions.

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NCT06489782

Developing a Novel Human Laboratory Paradigm for AUD Medication Screening

Recruiting
NAAges 21–65Interventional
Yale University
~90 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Model 1Model 2

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Alcohol consumption
Measured over 120 minutes
Alcohol Use Disorder
1 sites across 1 states
Connecticut1
  • Sherry McKee, PhD · PRINCIPAL_INVESTIGATOR · Yale University

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  • Alcohol consumption120 minutes

    Means mls of alcohol consumed during 120 minute alcohol self-administration sessions