Menopause Transition and Vascular Function Study
This study is looking at how the menopause transition affects your body's automatic functions (like heart rate and blood pressure) and blood vessel health. Researchers want to understand why women after menopause might have different responses to stress compared to men or younger women. This is an observational study, meaning there are no interventions or treatments being tested. We are looking for women aged 45-55 who are premenopausal and not taking medications that affect automatic body functions. The study will measure nerve activity related to blood pressure over up to 5 years to see how these changes occur during menopause.
- Study design
- This is an observational study, meaning there are no interventions or treatments. It plans to enroll 100 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for up to 5 years to measure nerve activity.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Manda Keller-Ross · PRINCIPAL_INVESTIGATOR · University of Minnesota
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- MSNA- Burst frequencyup to 5 years
measured in bursts/min Microneurography to measure MSNA: Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves. A tungsten microelectrode is placed in a peripheral nerve (Figure 8) to record real-time activity from efferent sympathetic vasoconstrictor nerve fibers. MSNA is the gold-standard measure for sympathetic activity Participants attend experimental visits annually until they enter perimenopause, at which point they will attend such visits every six months.
- MSNA- Burst incidenceup to 5 years
measured in bursts/100 heartbeats Microneurography to measure MSNA: Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves. A tungsten microelectrode is placed in a peripheral nerve (Figure 8) to record real-time activity from efferent sympathetic vasoconstrictor nerve fibers. MSNA is the gold-standard measure for sympathetic activity Participants attend experimental visits annually until they enter perimenopause, at which point they will attend such visits every six months.
- MSNA- total activityup to 5 years
Microneurography to measure MSNA: Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves. A tungsten microelectrode is placed in a peripheral nerve (Figure 8) to record real-time activity from efferent sympathetic vasoconstrictor nerve fibers. MSNA is the gold-standard measure for sympathetic activity Participants attend experimental visits annually until they enter perimenopause, at which point they will attend such visits every six months.