Exercise for Myasthenia Gravis

This study is looking at how well light versus moderate intensity exercise programs work for adults with Myasthenia Gravis (MG), a condition that causes muscle weakness. Researchers want to see if these exercise programs are practical, acceptable, and tolerable for people with MG. You could join if you are 18-80 years old, have generalized MG, and have been on stable MG medication for at least three months. The study will enroll 20 participants who will be randomly assigned to either a light or moderate intensity exercise group. The main goal is to see if these exercise programs are feasible, acceptable, and tolerable after 12 weeks.

Study design
This is an interventional study that will enroll 20 participants with Myasthenia Gravis. Participants will be randomly assigned to either a light or moderate intensity exercise group.
What's involved
You would participate in a small group exercise program three times a week for 12 weeks. The exercise program is called NeuroWell.
Compensation
Not stated in the trial record.
Follow-up
The main study outcomes are measured at 12 weeks, which is the end of the exercise program.

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NCT06491238

Light vs. Moderate Intensity Exercise in Individuals With Myasthenia Gravis

Recruiting
NAAges 18–80InterventionalTreatment
HealthPartners Institute
~20 participants
Updated 2026-03-23 on ClinicalTrials.gov
What's tested:Light Intensity ExerciseModerate Intensity Exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of light and moderate intensity exercise
Measured over 12 weeks
+2 more outcomes measured
Myasthenia Gravis
1 sites across 1 states
Minnesota1

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Eligibility criteria

Inclusion

Ability to provide and provision of signed and dated informed consent form.
Age 18-80
Diagnosis of generalized MG.
On a stable MG prescription medication regimen for the last 3 months.

Exclusion

Non-English speaking
Regular exercise participation within the month prior to study enrollment or any outside exercise participation during the study intervention period.
Significant cognitive impairment of any etiology that would impact study participation.
History of heart failure, chronic lung disease, angina or any other condition that causes unreasonable shortness of breath on exertion.
History of any serious neurological, psychiatric, or substance use disorders that would impact study participation.
Women who are currently pregnant or planning to become pregnant during the study.
Any other medical conditions that could affect their ability to participate in exercise for the study duration (as determined by study investigators).
Active participation or past participation ≤3 months in any other interventional research study.
Unwilling to participate in all study related activities.
  • Feasibility of light and moderate intensity exercise12 weeks

    Percent of participants recruited of potential participants contacted. Range: \[0-100\]. Higher percentage indicates higher feasibility

  • Acceptability of light and moderate intensity exercise12 weeks

    Percent of participants who complete the program of participants who start the program. Range: \[0-100\]. Higher percentage indicates higher acceptability

  • Tolerability of light and moderate intensity exercise12 weeks

    Percent of classes participants complete during the course of the program. Range: \[0-100\]. Higher percentage indicates higher tolerability.