Antibiotic Duration for Children Hospitalized with Pneumonia

This study is looking at whether a shorter, 5-day course of antibiotics works as well as the usual 7-14 day course for children hospitalized with uncomplicated community-acquired pneumonia (a lung infection caught outside of a hospital). Researchers want to see if drugs like ampicillin, ceftriaxone, amoxicillin, ampicillin/sulbactam, and amoxicillin-clavulanate can be given for a shorter time without affecting treatment success. They also want to know if a shorter course causes fewer side effects. Children aged 3 months to 18 years who are hospitalized with this type of pneumonia can join. The study will measure if the treatment is successful 14 days after the first antibiotic dose. The current recruitment status is unclear.

Study design
This is an open-label, randomized study aiming to enroll 236 participants. Participants will be assigned by chance to either a 5-day antibiotic course or a standard-length course.
What's involved
Participants will receive antibiotics, with the specific drugs and initial duration decided by their doctor. Other medical care will be guided by the primary treating doctor.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed up for treatment failure rate at 14 days from the first dose of antibiotics.

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NCT06494072

Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP

Recruiting
PHASE4Ages 3–18InterventionalTreatment
Medical College of Wisconsin
~236 participants
Updated 2026-03-02 on ClinicalTrials.gov
What's tested:Ampicillin for InjectionCeftriaxone for InjectionAmoxicillinAmpicillin / Sulbactam InjectionAmoxicillin-clavulanateClindamycin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Treatment failure rate
Measured over 14 days from the first dose antibiotics
Community Acquired Pneumonia in Children
1 sites across 1 states
Wisconsin1
  • Michelle Mitchell · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin

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  • Treatment failure rate14 days from the first dose antibiotics

    Treatment failure is defined as the clinical need for additional antibiotic treatment, an emergency department (ED) visit, or readmission to the hospital for a suspected lower respiratory tract infection within 14 days of treatment initiation.