Antibiotic Duration for Children Hospitalized with Pneumonia
This study is looking at whether a shorter, 5-day course of antibiotics works as well as the usual 7-14 day course for children hospitalized with uncomplicated community-acquired pneumonia (a lung infection caught outside of a hospital). Researchers want to see if drugs like ampicillin, ceftriaxone, amoxicillin, ampicillin/sulbactam, and amoxicillin-clavulanate can be given for a shorter time without affecting treatment success. They also want to know if a shorter course causes fewer side effects. Children aged 3 months to 18 years who are hospitalized with this type of pneumonia can join. The study will measure if the treatment is successful 14 days after the first antibiotic dose. The current recruitment status is unclear.
- Study design
- This is an open-label, randomized study aiming to enroll 236 participants. Participants will be assigned by chance to either a 5-day antibiotic course or a standard-length course.
- What's involved
- Participants will receive antibiotics, with the specific drugs and initial duration decided by their doctor. Other medical care will be guided by the primary treating doctor.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed up for treatment failure rate at 14 days from the first dose of antibiotics.
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Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Michelle Mitchell · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin
Who to contact
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What this trial measures
- Treatment failure rate14 days from the first dose antibiotics
Treatment failure is defined as the clinical need for additional antibiotic treatment, an emergency department (ED) visit, or readmission to the hospital for a suspected lower respiratory tract infection within 14 days of treatment initiation.